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Proteins/UNIPROT:A0A1W2PPD8

KDM4F

Protein·UNIPROT:A0A1W2PPD8Probable lysine-specific demethylase 4F

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Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code..

Function from UniProtKB (A0A1W2PPD8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

3 statements

3 statements · 3 reference databases · Subject: KDM4F · Sources: gene ontology, Rhea, UniProt

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KDM4F regulates regulation of gene expressionBiological processgene ontology A0A1W2PPD8|GO:0010468Inferred only
KDM4F requires the cofactor iron(2+)CompoundUniProt A0A1W2PPD8Inferred only
formaldehyde is a substrate of KDM4FCompoundRhea RHEA:60200Inferred only

Reactions

1 reaction

N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3]+22-oxoglutarate(2-)+2dioxygenN(6)-methyl-L-lysyl(9)-[histone H3]+2formaldehyde+2succinate(2-)+2carbon dioxide
Catalysed by KDM4F or KDM4E or KDM4A or KDM4B or KDM4D or KDM4C
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:60200CC BY 4.0Reference data

Other names

1 name

Resolves to: KDM4F

Also called: Probable lysine-specific demethylase 4F

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