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Proteins/UNIPROT:O15550
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity)..
Function from UniProtKB (O15550), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
74 statements
74 statements · 7 reference databases · Subject: KDM6A · Sources: gene ontology, Hetionet, Human Protein Atlas, Reactome, Rhea, UniProt, WikiPathways
1 reaction
N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3]+22-oxoglutarate(2-)+2dioxygenN(6)-methyl-L-lysyl(27)-[histone H3]+2formaldehyde+2succinate(2-)+2carbon dioxide
Catalysed by UTY or KDM6B or KDM6A
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:60224CC BY 4.0Reference data
5 names
Resolves to: KDM6A