Proteins/UNIPROT:Q96Q83

ALKBH3

ProteinUNIPROT:Q96Q83Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron..

Function from UniProtKB (Q96Q83), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

14 statements

14 statements · 6 reference databases · Subject: ALKBH3 · Sources: gene ontology, Hetionet, Reactome, Rhea, UniProt, WikiPathways

Order

ADAMTS7 covaries with ALKBH3ProteinHetionet hetionet:covaries:11173-221120Inferred only
DCAF16 covaries with ALKBH3ProteinHetionet hetionet:covaries:221120-54876Inferred only
RDM1 covaries with ALKBH3ProteinHetionet hetionet:covaries:201299-221120Inferred only
SRPK1 interacts with ALKBH3ProteinHetionet hetionet:interacts:221120-6732Inferred only
SRPK2 interacts with ALKBH3ProteinHetionet hetionet:interacts:221120-6733Inferred only
ALKBH3 participates in 11p11 2 copy number variation syndrome PathwayWikiPathways WP5348Inferred only
ALKBH3 participates in ALKBH3 mediated reversal of alkylation damagePathwayReactome R-HSA-112126Inferred only
ALKBH3 participates in Direct reversal repairPathwayWikiPathways WP4931Inferred only
ALKBH3 participates in DNA Damage ReversalPathwayReactome R-HSA-73942Inferred only
ALKBH3 participates in DNA RepairPathwayReactome R-HSA-73894Inferred only
ALKBH3 participates in Reversal of alkylation damage by DNA dioxygenasesPathwayReactome R-HSA-73943Inferred only
ALKBH3 regulates negative regulation of cytoplasmic translationBiological processgene ontology Q96Q83|GO:2000766Inferred only

Show the remaining 2

ALKBH3 requires the cofactor iron(2+)CompoundUniProt Q96Q83Inferred only
formaldehyde is a substrate of ALKBH3CompoundRhea RHEA:49516Inferred only

Reactions

5 reactions

a methylated nucleobase within DNA+2-oxoglutarate(2-)+dioxygena nucleobase within DNA+formaldehyde+succinate(2-)+carbon dioxide
Catalysed by ALKBH1 or ALKBH2 or ALKBH3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:30299CC BY 4.0Reference data
an N(1)-methyladenosine in mRNA+2-oxoglutarate(2-)+dioxygen

Other names

6 names

Resolves to: ALKBH3

Also called: ABH3Alkylated DNA repair protein alkB homolog 3DEPC-1DEPC1hABH3Prostate cancer antigen 1

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