Proteins/UNIPROT:Q96DX5

ASB9

ProteinUNIPROT:Q96DX5

Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The ECS(ASB9) complex catalyzes ubiquitination of creatine kinases CKB and CKMT1A..

[Isoform 2]: Does not interact with the Elongin BC complex, likely to be a negative regulator of isoform 1..

Function from UniProtKB (Q96DX5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 3 reference databases · Subject: ASB9 · Sources: gene ontology, Hetionet, Reactome

Order

CKB interacts with ASB9ProteinHetionet hetionet:interacts:1152-140462Inferred only
CKM interacts with ASB9ProteinHetionet hetionet:interacts:1158-140462Inferred only
CKMT1A interacts with ASB9ProteinHetionet hetionet:interacts:1159-140462Inferred only
ASB9 interacts with CKMT1AProteinHetionet hetionet:interacts:140462-548596Inferred only
ELOC interacts with ASB9ProteinHetionet hetionet:interacts:140462-6921Inferred only
HIF1AN interacts with ASB9ProteinHetionet hetionet:interacts:140462-55662Inferred only
UBE2D1 interacts with ASB9ProteinHetionet hetionet:interacts:140462-7321Inferred only
ASB9 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
ASB9 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
ASB9 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
ASB9 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
ASB9 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only

Show the remaining 7

ASB9 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
ASB9 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
ASB9 regulates positive regulation of protein catabolic processBiological processgene ontology Q96DX5|GO:0045732Inferred only
ATG7 decreases the expression of ASB9ProteinHetionet hetionet:regulates:10533-140462Inferred only
COQ8A decreases the expression of ASB9ProteinHetionet hetionet:regulates:56997-140462Inferred only
GLRX decreases the expression of ASB9ProteinHetionet hetionet:regulates:2745-140462Inferred only
ZNF296 decreases the expression of ASB9ProteinHetionet hetionet:regulates:162979-140462Inferred only

Other names

2 names

Resolves to: ASB9

Also called: Ankyrin repeat and SOCS box protein 9ASB-9

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