Proteins/UNIPROT:Q6ZSG1

ARK2C

ProteinUNIPROT:Q6ZSG1

E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL..

Function from UniProtKB (Q6ZSG1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 2 reference databases · Subject: ARK2C · Sources: gene ontology, Hetionet

Order

ARK2C covaries with ADCY6ProteinHetionet hetionet:covaries:112-494470Inferred only
GATA2 covaries with ARK2CProteinHetionet hetionet:covaries:2624-494470Inferred only
ARK2C covaries with NDNProteinHetionet hetionet:covaries:4692-494470Inferred only
SPRY3 covaries with ARK2CProteinHetionet hetionet:covaries:10251-494470Inferred only
SYT5 covaries with ARK2CProteinHetionet hetionet:covaries:494470-6861Inferred only
UBE2D1 interacts with ARK2CProteinHetionet hetionet:interacts:494470-7321Inferred only
UBE2D2 interacts with ARK2CProteinHetionet hetionet:interacts:494470-7322Inferred only
UBE2D3 interacts with ARK2CProteinHetionet hetionet:interacts:494470-7323Inferred only
UBE2D4 interacts with ARK2CProteinHetionet hetionet:interacts:494470-51619Inferred only
UBE2E1 interacts with ARK2CProteinHetionet hetionet:interacts:494470-7324Inferred only
UBE2E3 interacts with ARK2CProteinHetionet hetionet:interacts:10477-494470Inferred only
UBE2N interacts with ARK2CProteinHetionet hetionet:interacts:494470-7334Inferred only

Show the remaining 1

ARK2C regulates positive regulation of BMP signaling pathwayBiological processgene ontology Q6ZSG1|GO:0030513Inferred only

Other names

2 names

Resolves to: ARK2C

Also called: RING finger protein 165RNF165

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