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Proteins/UNIPROT:O60502
[Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity..
[Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1..
Function from UniProtKB (O60502), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
186 statements
186 statements · 3 reference databases · Subject: OGA · Sources: Bgee, Hetionet, Rhea
2 reactions
3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein]+waterN-acetyl-D-glucosamine+L-seryl-[protein]
Catalysed by OGA
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:48876CC BY 4.0Reference data
3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein]+waterL-threonyl-[protein]+N-acetyl-D-glucosamine
Catalysed by OGA
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:48892CC BY 4.0Reference data
12 names
Resolves to: OGA