Proteins/UNIPROT:Q86SM8

MRGPRE

ProteinUNIPROT:Q86SM8

G protein-coupled receptor for L-tryptophanocholate (Trp-CA), an amino-acid-conjugated bile acid produced by the microbiome, which regulates glucose homeostasis. Expressed in enteroendocrine L cells of the gut epithelium: Trp-CA binding causes a conformation change that triggers signaling via G(s) G protein, mediating activation of adenylate cyclase activity. In addition to G(s), MRGPRE also associates with beta-arrestin-1 (ARRB1), promoting phosphorylation of ALDOA. Both G(s) and beta-arrestin-1 signaling pathways improves glucose tolerance by enhancing GLP-1 secretion..

Function from UniProtKB (Q86SM8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 2 reference databases · Subject: MRGPRE · Sources: gene ontology, Hetionet

Order

ACAA2 covaries with MRGPREProteinHetionet hetionet:covaries:10449-116534Inferred only
ATP7B covaries with MRGPREProteinHetionet hetionet:covaries:116534-540Inferred only
CALD1 covaries with MRGPREProteinHetionet hetionet:covaries:116534-800Inferred only
CMTM6 covaries with MRGPREProteinHetionet hetionet:covaries:116534-54918Inferred only
DSG2 covaries with MRGPREProteinHetionet hetionet:covaries:116534-1829Inferred only
PLPP6 covaries with MRGPREProteinHetionet hetionet:covaries:116534-403313Inferred only
MRGPRE covaries with SLC25A24ProteinHetionet hetionet:covaries:116534-29957Inferred only
TM4SF5 covaries with MRGPREProteinHetionet hetionet:covaries:116534-9032Inferred only
MRGPRE regulates positive regulation of insulin secretion involved in cellular response to glucose stimulusBiological processgene ontology Q86SM8|GO:0035774Inferred only

Other names

4 names

Resolves to: MRGPRE

Also called: G protein-coupled receptor 167GPR167Mas-related G protein-coupled receptor member EMRGE

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