Catalyst

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Search ?

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

Reach

20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

241 compounds within 3 steps: 4 in 1, 53 in 2, 184 in 3

Does it reach a compound?

Two steps

prostaglandin E2Reach from here →
1. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
2. transport of prostaglandin E2 (cytosol to extracellular)
Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes
L-cysteinylglycineReach from here →
1. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
2. glutathione gamma-glutamylaminopeptidase
Catalysed by SLCO2A1, GGTLC3, GGT1, GGT5 and 3 moreextracellular space, cytosolOne of 4 routes
(R)-noradrenalineReach from here →
1. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
2. transport of noradrenaline (cytosol to extracellular)
Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes
ursodeoxycholateReach from here →
1. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes
prostaglandin G2Reach from here →
1. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
2. transport of prostaglandin G2 (cytosol to extracellular)
Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes
thromboxane B2Reach from here →
1. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes
taurochenodeoxycholateReach from here →
1. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
2. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)
Catalysed by SLCO1B1, SLCO1A2, SLC7A9, SLCO1B3extracellular space, cytosolOne of 4 routes

Three steps

(S)-carnitineReach from here →
Catalysed by SLCO1B1extracellular space, cytosol, endoplasmic reticulumOne of 2 routes
CHEBI:1146900Reach from here →
Catalysed by SLCO1B1, SLCO1A2

Page 2 of 5

, SLCO1B3

, AANAT

extracellular space, cytosol

One of 4 routes

(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
Glutathione: 15-HPETE oxidoreductase
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 7 moreextracellular space, cytosol

AReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DIO1 and 1 moreextracellular space, cytosolOne of 8 routes

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP3A4 and 5 moreextracellular space, cytosol

(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP3A4 and 5 moreextracellular space, cytosol

(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP2C8, CYP2C9, CYP2C19 and 2 moreextracellular space, cytosol

(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1, CYP2C8, CYP2D6 and 4 moreextracellular space, cytosol

(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP2C9, CYP2J2extracellular space, cytosol

(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1, CYP2D6, CYP2C9 and 3 moreextracellular space, cytosol

5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 4 routes

17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 2 routes

16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1extracellular space, cytosol

10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP3A4, CYP2C9extracellular space, cytosol

prostaglandin J2Reach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of prostaglandin D2 (cytosol to extracellular)
prostaglandin J2 hydrolysis

Catalysed by SLCO1B1extracellular space, cytosolOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of prostaglandin F2alpha (cytosol to extracellular)
15-keto-prostaglandin F2alpha reduction

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

dopamine 3-O-sulfateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of dopamine (cytosol to extracellular)
dopamine + 3'-phosphoadenylyl sulfate = dopamine 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1B1 and 3 moreextracellular space, cytosol

dopamine 4-O-sulfateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of dopamine (cytosol to extracellular)
Dopamine 4-O-Sulfotransferase

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 1 moreextracellular space, cytosolOne of 2 routes

hyocholateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
solute carrier organic anion transporter (chenodiol)
Chenodeoxycholic acid 6alpha-hydroxylase

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, CYP3A4extracellular space, cytosol

prostaglandin A2-S-(R)-glutathioneReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of prostaglandin A2 (cytosol to extracellular)
prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

Catalysed by SLCO1B1, GSTA1, GSTM1extracellular space, cytosol

prostaglandin A2-S-(S)-glutathioneReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of prostaglandin A2 (cytosol to extracellular)
prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

Catalysed by SLCO1B1, GSTP1, GSTM1extracellular space, cytosol

(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

Catalysed by SLCO1B1, ALOX15extracellular space, cytosol

(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

Catalysed by SLCO1B1, ALOX15extracellular space, cytosol

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

Catalysed by SLCO1B1, PM20D1extracellular space, cytosol

7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 2 routes

13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 2 routes

13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP2C9extracellular space, cytosol

chenodeoxycholoyl-24-O-(beta-D-glucuronate)Reach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
solute carrier organic anion transporter (chenodiol)
chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, UGT2A2 and 1 moreextracellular space, cytosol

16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosol

N-(4-oxoglutaryl)-L-cysteinylglycineReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
glutathione gamma-glutamylaminopeptidase
N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate

Catalysed by SLCO2A1, GGTLC3, GGT1, GGT5 and 4 moreextracellular space, cytosol

beta-D-glucosyl-(1->3)-O-chenodeoxycholateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
solute carrier organic anion transporter (chenodiol)
a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + a di-trans,poly-cis-dolichyl phosphate + H(+)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, GBA2extracellular space, cytosolOne of 2 routes

L-cystine-bis-glycineReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
glutathione gamma-glutamylaminopeptidase
2 L-cysteinylglycine + [protein]-disulfide = L-cystine-bis-glycine + [protein]-dithiol

Catalysed by SLCO2A1, GGTLC3, GGT1, GGT5 and 4 moreextracellular space, cytosol

8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion

Catalysed by SLCO1B1extracellular space, cytosolOne of 2 routes

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

Catalysed by SLCO1B1, FAAH, PM20D1extracellular space, cytosol

(15S)-15-hydroperoxy-prostaglandin E2Reach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of prostaglandin G2 (cytosol to extracellular)
prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2

Catalysed by SLCO1B1, PTGESextracellular space, cytosol

cholineReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of acetylcholine (cytosol to extracellular)
Acetylcholine aectylhydrolase

Catalysed by SLCO1B1, SLCO1B3, BCHE, ACHEextracellular space, cytosolOne of 5 routes

pyruvateReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
cystine to cysteine conversion
L-cysteine hydrogen-sulfide-lyase (deaminating

Catalysed by SLCO2A1, CTHextracellular space, cytosolOne of 2 routes

arachidonoyl-CoAReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
Arachidonate:CoA ligase (AMP-forming)

Catalysed by SLCO1B1, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, cytosolOne of 3 routes

CHEBI:15519Reach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
solute carrier organic anion transporter (cholate)
Cholate:CoA ligase (AMP-forming)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC27A2 and 1 moreextracellular space, cytosol, endoplasmic reticulum

L-leucineReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
cystine to cysteine conversion
transport of cysteine and leucine (cytosol to extracellular)

Catalysed by SLCO2A1, SLC7A9, SLC3A1extracellular space, cytosolOne of 3 routes

12(S)-HPETEReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
arachidonate:oxygen 12-oxidoreductase

Catalysed by SLCO1B1, ALOX12extracellular space, cytosolOne of 4 routes

15(S)-HPETEReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
arachidonate:oxygen 15-oxidoreductase

Catalysed by SLCO1B1, ALOX15B, ALOX15extracellular space, cytosolOne of 6 routes

5(S)-HPETEReach from here →

Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
transport of arachidonate (cytosol to extracellular)
Arachidonate:oxygen 5-oxidoreductase

Catalysed by SLCO1B1, ALOX5extracellular space, cytosol