(8Z,11Z,14Z)-eicosatrienoyl-CoA

Three steps

• 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)

  Catalysed by LCLAT1, LPCAT1, GPAM, PLA2G15 and 1 morecytosolOne of 2 routes

• 3-oxo-(11Z)-octadecenoyl-CoAReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 11 morecytosol

• 3-oxo-(13Z)-eicosenoyl-CoAReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
  3. (11Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol

• 1-O-alkyl-2,3-diacyl-sn-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  3. 1-O-alkyl-2-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-2,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine

  Catalysed by LPGAT1, PLA2G15cytosolOne of 2 routes

• (25R)-cholest-5-ene-3beta,26-diolReach from here →
  1. Acyl-CoA:cholesterol O-acyltransferase
  2. Steryl-ester acylhydrolase
  3. cholesterol,NADPH:oxygen oxidoreductase (5alpha,6alpha-epoxidizing)

  Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 moreendoplasmic reticulum, lysosome, mitochondrial matrix

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
  2. Arachidonyl-CoA hydrolase
  3. arachidonic acid:oxygen 1-oxidoreductase

  Catalysed by FADS1, ACOT7, BAAT, THEM4 and 29 morecytosolOne of 3 routes

• 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →
  1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
  2. Arachidonyl-CoA hydrolase
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by FADS1, ACOT7, BAAT, THEM4 and 3 morecytosol

• 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
  2. Arachidonyl-CoA hydrolase
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by FADS1, ACOT7, BAAT, THEM4 and 7 morecytosol

• 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

• 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

• O-dodecanoyl-R-carnitineReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase
  3. carnitine O-palmitoyltransferase (dodecanoylcarnitine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 11 routes

• 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphateReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-octadecanoyl-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

• 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. 1-octadecanoyl-sn-glycero-3-phosphate + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

• (11Z,14Z)-eicosadienoateReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
  3. (11Z,14Z)-eicosadienoyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosolOne of 13 routes

• (17Z)-hexacosenoateReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (ximenic acid)
  3. Hexacosenoyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosolOne of 13 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (DPA)
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosolOne of 13 routes

• (7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
  1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
  2. fatty-acyl-CoA elongation (N-C20:4CoA)
  3. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase

  Catalysed by FADS1, ELOVL4, ELOVL6, ELOVL2 and 3 morecytosolOne of 14 routes

• 2,6,10,14-tetramethylpentadecanoateReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. fatty-acid-CoA ligase
  3. peroxisomal acyl-CoA thioesterase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, peroxisomeOne of 2 routes

• a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT2, LPCAT1cytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPCAT4cytosol

• 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, mitochondrial matrix

• 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosol

• tetracosan-1-olReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. tetracosanoyl-CoA + 2 NADPH + 2 H(+) = tetracosan-1-ol + 2 NADP(+) + CoA

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

• (2E,9Z)-hexadecadienoyl-CoAReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 13 morecytosol, mitochondrial matrixOne of 3 routes

• trans-2-heptadecenoyl-CoAReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (margaric acid)
  3. medium-chain acyl-CoA dehydrogenase (heptadecanoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 13 morecytosol, mitochondrial matrixOne of 2 routes

• (2E,9Z)-octadecadienoyl-CoAReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. Transport of octadecenoyl-CoA into Mitochondrial Matrix
  3. medium-chain acyl-CoA dehydrogenase (oleoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 8 morecytosol, mitochondrial matrixOne of 2 routes

• (2E,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 12 morecytosol

• (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoAReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + O2 = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H2O2

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol

• 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serineReach from here →
  1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA
  3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + hexadecanoate + H(+)

  Catalysed by FADS1, LPCAT3, PLA1A

• N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 6 morecytosol, Golgi apparatus

• (5Z,8Z,11Z)-eicosatrienoateReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol, extracellular spaceOne of 12 routes

• 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + octadecanoate + H(+)

  Catalysed by FADS1, AGPAT3, DDHD1

• 9-cis-retinolReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol = 9-cis-retinol

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosol

• 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1-(1Z-octadecenyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by FADS1, LPCAT3, TMEM164

• N-hexadecanoyl-sphinganine-1-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by LPGAT1, SGMS1, SGMS2cytosol

• N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by LPGAT1, SGMS1, SGMS2cytosol

• an N-acyl-(4R)-4-hydroxysphinganine-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by LPGAT1, SGMS1, SGMS2cytosol

• N-hexadecanoyl-sphinganine-1-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-sphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2 and 2 morecytosol

• an N-acylsphinganine-1-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. sphingosine N-acyltransferase (sphinganine)
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 morecytosolOne of 2 routes

• N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
  3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2 and 2 morecytosol

• an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
  3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2 and 2 morecytosol

• (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
  2. Arachidonyl-CoA hydrolase
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O

  Catalysed by FADS1, ACOT7, BAAT, THEM4 and 3 morecytosolOne of 2 routes

• (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
  2. Arachidonyl-CoA hydrolase
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by FADS1, ACOT7, BAAT, THEM4 and 3 morecytosolOne of 2 routes

• hexadecanoateReach from here →
  1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

  Catalysed by FADS1, LPCAT3, MBOAT7, PLA2G4B and 5 moreOne of 3 routes

• tricosanoateReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
  3. Tricosanoyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosolOne of 13 routes

• (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
  2. Arachidonyl-CoA hydrolase
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by FADS1, ACOT7, BAAT, THEM4 and 3 morecytosol

• 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
  2. Arachidonyl-CoA hydrolase
  3. Arachidonate: oxygen 11-oxidoreductase

  Catalysed by FADS1, ACOT7, BAAT, THEM4 and 3 morecytosolOne of 2 routes

• prostaglandin G2Reach from here →
  1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
  2. Arachidonyl-CoA hydrolase
  3. Arachidonate:oxygen oxidoreductase

  Catalysed by FADS1, ACOT7, BAAT, THEM4 and 4 morecytosol, endoplasmic reticulumOne of 2 routes

• thio-Mo-molybdopterinReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, mitochondrial matrix

• cholesteryl octadecanoateReach from here →
  1. Dihomo-gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol, endoplasmic reticulumOne of 7 routes