2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate

1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)

Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 7 morecytosolOne of 3 routes

1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol

Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 8 morecytosol

1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol

Catalysed by PLPP1, and 8 more

1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. Utilized Transport

Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 8 morecytosol, endoplasmic reticulumOne of 2 routes

1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O