(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

128 compounds within 3 steps: 1 in 1, 35 in 2, 92 in 3

Three steps

10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 4 more
(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 more
(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 more
2,4-dinitrophenyl-S-glutathioneReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. transport of arachidonate (cytosol to extracellular)
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 moreextracellular space, cytosolOne of 2 routes
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 more
7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. unspecific monooxygenase (arachidonate)
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 28 morecytosolOne of 2 routes
13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. unspecific monooxygenase (arachidonate)
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 28 morecytosolOne of 2 routes
13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 more
16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. unspecific monooxygenase (arachidonate)
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 28 morecytosol
1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine
Catalysed by ACAA1, LPCAT3, ALOX15B
8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 2 morecytosolOne of 2 routes
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 4 more
arachidonoyl-CoAReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. Arachidonate:CoA ligase (AMP-forming)
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 10 morecytosolOne of 3 routes
12(S)-HPETEReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. arachidonate:oxygen 12-oxidoreductase
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 morecytosolOne of 4 routes
15(S)-HPETEReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. arachidonate:oxygen 15-oxidoreductase
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 4 morecytosolOne of 4 routes
5(S)-HPETEReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. Arachidonate:oxygen 5-oxidoreductase
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 morecytosol
CHEBI:16856Reach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. transport of arachidonate and GSH (cytosol to extracellular)
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 2 moreextracellular space, cytosolOne of 2 routes
1-acyl-sn-glycerol 3-phosphateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
3. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
Catalysed by ACAA1, GPAT2cytosolOne of 8 routes
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoate + H(+)
Catalysed by ACAA1, MBOAT7, DDHD1One of 3 routes
O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 8 more
octadecanoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoate + H(+)
Catalysed by ACAA1, MBOAT7, DDHD1One of 2 routes
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. fatty acylamide amidohydrolase
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 morecytosol
a fatty acidReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
3. a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)
Catalysed by ACAA1, MBOAT7, AGPAT3, DDHD1One of 3 routes
(9Z)-octadecenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA
3. 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)
Catalysed by ACAA1, AGPAT3, AGPAT5, DDHD1
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerolReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
3. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate
Catalysed by ACAA1, GPAT2, EPHX2
fatty acidReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. (10Z)-heptadecenoic acid formation
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 2 morecytosolOne of 4 routes
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. fatty acid amide hydrolase (2-arachidonoylglycerol)
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 morecytosol
glycineReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
Catalysed by ACAA1, GLYATL2, FAAH, PM20D1
octadecanoyl-CoAReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by ACAA1, LPCAT3, LPGAT1
prostaglandin H2Reach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. prostaglandin-endoperoxide synthase (arachidonate)
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 4 morecytosolOne of 3 routes
(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 5 more
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 5 more
(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 more
leukotriene A4Reach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 more
a 1-acyl-sn-glycero-3-phosphocholineReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by ACAA1, LPCAT3, PNPLA8
18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. cytochrome P450 (arachidonate)
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 moreendoplasmic reticulumOne of 2 routes
a 1-acyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. a 1-acyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA
3. 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by ACAA1, LPCAT4, LPCAT3, PLA2G15 and 1 more
1-O-hexadecyl-sn-glycero-3-phosphocholineReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
3. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by ACAA1, LPCAT4, PLA2G6, PLA2G4A and 2 more
1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ACAA1, LPCAT3, MBOAT7, PLA2G15One of 5 routes
1-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
Catalysed by ACAA1, LPCAT3, PLA2G15One of 2 routes
1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by ACAA1, LPCAT3, PLA2G10, PLA2G6 and 1 moreOne of 4 routes
1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by ACAA1, MBOAT7, PLA2G5
1-octadecanoyl-sn-glycero-3-phosphateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by ACAA1, AGPAT3, PLA2G4A
1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
3. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
Catalysed by ACAA1, GPAT2, GPAT3, ABHD5 and 1 more
(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 more
(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. Arachidonate:oxygen 8-oxidoreductase
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 morecytosolOne of 2 routes
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
Catalysed by ACAA1, LPCAT3, PLA2G4A
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerolReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate
Catalysed by ACAA1, AGPAT3, LPIN1
2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerolReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)
3. fatty acid amide hydrolase (arachidonate)
Catalysed by ACAA1, ACOT8, THEM4, THEM5 and 3 morecytosol
1-octadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
1. (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + acetyl-CoA
2. 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
Catalysed by ACAA1, LPCAT3, PLA2G15