3-oxodocosanoyl-CoA

Three steps

• L-asparagineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 2 moreperoxisome, cytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 2 moreperoxisome, cytosol, mitochondrial matrix

• (3Z)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 4 moreperoxisome, cytosol, mitochondrial matrixOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, AGPAT2, GPAT3 and 11 moreperoxisome, cytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 3 moreperoxisome, cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 3 moreperoxisome, cytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 7 moreperoxisome, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 4 moreperoxisome, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 12 routes

• a cardiolipinReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA

  Catalysed by ACAA1, MYO5B, HADHAperoxisome, cytosol

• 3-hydroxyisovaleryl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 3 moreperoxisome, cytosol

• an all-trans-retinyl esterReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA

  Catalysed by ACAA1, MYO5B, DGAT1, PNPLA4 and 2 moreperoxisome, cytosol

• CHEBI:63544Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 8 routes

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, MYO5B, LPCAT4, LPCAT3 and 2 moreperoxisome, cytosol

• a triacyl-sn-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by ACAA1, MYO5B, DGAT1, MOGAT2 and 4 moreperoxisome, cytosol

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by ACAA1, MYO5B, LCLAT1, LPCAT1 and 1 moreperoxisome, cytosol

• hexacosanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 6 routes

• tetracosanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 11 routes

• 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• docosanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 10 routes

• 3-oxoeicosasphinganineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. octadecanoyl-CoA + L-serine + H(+) = 3-oxoeicosasphinganine + CO2 + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 3 moreperoxisome, mitochondrial matrix

• 3-oxoeicosanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 7 moreperoxisome, mitochondrial matrix, cytosolOne of 2 routes

• N-(octadecanoyl)-sphinganineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 6 moreperoxisome, mitochondrial matrix

• (2E)-octadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 4 moreperoxisome, cytosolOne of 9 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 9 routes

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 2 moreperoxisome, mitochondrial matrix

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• N-octadecanoylsphing-4-enineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 4 moreperoxisome, mitochondrial matrix

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 10 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 7 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 8 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 7 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 8 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 6 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 5 routes

• 2-hydroxyoctadecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• (15Z)-tetracosenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 7 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 5 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 6 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 6 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 8 routes

• heptadecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 7 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 6 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Eicosanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by ACAA1, MYO5B, BAAT, ACOT6 and 9 moreperoxisome, cytosolOne of 6 routes

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 6 moreperoxisome, mitochondrial matrix

• 1-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 4 moreperoxisome, mitochondrial matrix, cytosolOne of 2 routes

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 2 moreperoxisome, mitochondrial matrix

• 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxodocosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix