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Reach

S-formylglutathione

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

391 compounds within 3 steps: 5 in 1, 107 in 2, 279 in 3

Does it reach a compound?

Two steps

20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. S-Formylglutathione hydrolase
2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
Catalysed by ESD, SLCO2A1cytosol, extracellular spaceOne of 2 routes
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. S-formylglutathione + H2O = formate + glutathione + H(+)
2. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O
Catalysed by ESD, GPX1, GPX4
ursodeoxycholateReach from here →
1. S-Formylglutathione hydrolase
2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes
prostaglandin G2Reach from here →
1. S-Formylglutathione hydrolase
2. transport of GSH and prostaglandin G2 (cytosol to extracellular)
Catalysed by ESD, SLCO2A1cytosol, extracellular spaceOne of 2 routes
glycodeoxycholateReach from here →
1. S-formylglutathione + H2O = formate + glutathione + H(+)
2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
Catalysed by ESD, ABCC4inner side of the membrane, outer side of the membrane
(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. S-formylglutathione + H2O = formate + glutathione + H(+)
2. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by ESD, GPX1, GPX2, GPX4
(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. S-formylglutathione + H2O = formate + glutathione + H(+)
2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by ESD, PTGES, MGST3, GPX1 and 3 more
(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. S-formylglutathione + H2O = formate + glutathione + H(+)
2. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by ESD, GPX1, GPX4
thromboxane B2Reach from here →
1. S-Formylglutathione hydrolase
2. transport of GSH and thromboxane B2 (cytosol to extracellular)
Catalysed by ESD, SLCO1B1cytosol, extracellular spaceOne of 2 routes
an S-substituted glutathioneReach from here →
1. S-formylglutathione + H2O = formate + glutathione + H(+)
2. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)
Catalysed by ESD, GSTT4, GSTA4, GSTZ1 and 20 moreOne of 2 routes
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. S-formylglutathione + H2O = formate + glutathione + H(+)
2. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
Catalysed by ESD, GPX1, GSTA1, GPX2 and 1 more
taurochenodeoxycholateReach from here →
1. S-Formylglutathione hydrolase
2. solute carrier organic anion transporter (GSH)
Catalysed by ESD, SLCO1A2, SLC7A9, SLCO1B3cytosol, extracellular spaceOne of 3 routes

Three steps

(S)-3-hydroxybutanoateReach from here →
Catalysed by ESD, SLC16A4, SLC16A5, ADHFE1cytosol, extracellular space
(S)-carnitineReach from here →

Page 3 of 8

Catalysed by ESD, SLC26A4, SLC6A14

cytosol, extracellular space

One of 3 routes

CHEBI:1146900Reach from here →

S-Formylglutathione hydrolase
transport of GSH and leukotriene E4 (cytosol to extracellular)
N-acetyl-LTE4 to leukotriene E4 conversion

Catalysed by ESD, SLCO1B1, ZDHHC11B, NAA10 and 30 morecytosol, extracellular spaceOne of 4 routes

(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

S-Formylglutathione hydrolase
Glutathione: 15-HPETE oxidoreductase
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Catalysed by ESD, GPX5, GPX1, GPX2 and 7 morecytosol

AReach from here →

S-Formylglutathione hydrolase
transport of GSH and thyroxine (cytosol to extracellular)
3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

Catalysed by ESD, SLCO1A2, SLCO1B3, DIO1 and 1 morecytosol, extracellular spaceOne of 11 routes

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ESD, CYP1A1, CYP1A2, CYP3A4 and 5 morecytosol, extracellular space

(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ESD, CYP1A1, CYP1A2, CYP3A4 and 5 morecytosol, extracellular space

(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ESD, CYP2C8, CYP2C9, CYP2C19 and 2 morecytosol, extracellular space

(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ESD, CYP1A1, CYP2C8, CYP2D6 and 4 morecytosol, extracellular space

(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ESD, CYP2C9, CYP2J2cytosol, extracellular space

(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ESD, CYP1A1, CYP2D6, CYP2C9 and 3 morecytosol, extracellular space

5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by ESD, CYP1A1, CYP1A2, CYP2E1 and 23 morecytosol, extracellular spaceOne of 4 routes

17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by ESD, CYP1A1, CYP1A2, CYP2E1 and 23 morecytosol, extracellular spaceOne of 2 routes

16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ESD, CYP1A1cytosol, extracellular space

a quinoneReach from here →

S-formylglutathione + H2O = formate + glutathione + H(+)
a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)

Catalysed by ESD, SQOR, CYC1, UQCRFS1outer side of the membraneOne of 6 routes

10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ESD, CYP3A4, CYP2C9cytosol, extracellular space

prostaglandin J2Reach from here →

S-Formylglutathione hydrolase
transport of formate and L-lactate (cytosol to extracellular)
Transport of Prostaglandin J2, Lactate Antiport

Catalysed by ESD, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 4 routes

15-oxoprostaglandin F2alphaReach from here →

S-Formylglutathione hydrolase
transport of formate and L-lactate (cytosol to extracellular)
Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport

Catalysed by ESD, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 6 routes

dopamine 3-O-sulfateReach from here →

S-Formylglutathione hydrolase
transport of dopamine and GSH (cytosol to extracellular)
dopamine + 3'-phosphoadenylyl sulfate = dopamine 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by ESD, SLCO1A2, SLCO1B3, SULT1B1 and 3 morecytosol, extracellular space

dopamine 4-O-sulfateReach from here →

S-Formylglutathione hydrolase
transport of dopamine and GSH (cytosol to extracellular)
Dopamine 4-O-Sulfotransferase

Catalysed by ESD, SLCO1A2, SLCO1B3, SULT1A3 and 1 morecytosol, extracellular spaceOne of 2 routes

epsilon-(gamma-L-glutamyl)-L-lysineReach from here →

S-formylglutathione + H2O = formate + glutathione + H(+)
glutathione = L-cysteinylglycine + 5-oxo-L-proline
epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine

Catalysed by ESD, CHAC2, CHAC1, GGACT

(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

Catalysed by ESD, ALOX15cytosol, extracellular space

(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

Catalysed by ESD, ALOX15cytosol, extracellular space

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

Catalysed by ESD, PM20D1cytosol, extracellular space

all-trans-4-hydroxyretinoateReach from here →

S-Formylglutathione hydrolase
transport of formate and retinoate (cytosol to extracellular)
cytochrome P450 (retinoate)

Catalysed by ESD, SLC16A4, SLC16A5, CYP26A1cytosol, extracellular spaceOne of 3 routes

N-acetylcadaverineReach from here →

S-Formylglutathione hydrolase
transport of acetate and formate (cytosol to extracellular)
N-acetylcadaverine + H2O = cadaverine + acetate

Catalysed by ESD, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular space

7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by ESD, CYP1A1, CYP1A2, CYP2E1 and 23 morecytosol, extracellular spaceOne of 2 routes

13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by ESD, CYP1A1, CYP1A2, CYP2E1 and 23 morecytosol, extracellular spaceOne of 2 routes

13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ESD, CYP2C9cytosol, extracellular space

16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

S-Formylglutathione hydrolase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by ESD, CYP1A1, CYP1A2, CYP2E1 and 23 morecytosol, extracellular space

(5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

S-formylglutathione + H2O = formate + glutathione + H(+)
(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Catalysed by ESD, PTGES, MGST3, GPX1 and 4 more

N-(4-oxoglutaryl)-L-cysteinylglycineReach from here →

S-Formylglutathione hydrolase
glutathione gamma-glutamylaminopeptidase
N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate

Catalysed by ESD, GGTLC3, GGT1, GGT5 and 4 morecytosol

all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →

S-Formylglutathione hydrolase
transport of formate and retinoate (cytosol to extracellular)
glucuronosyltransferase (retinoate)

Catalysed by ESD, SLC16A4, SLC16A5, UGT1A1 and 2 morecytosol, extracellular space, endoplasmic reticulum

all-trans-18-hydroxyretinoateReach from here →

S-Formylglutathione hydrolase
transport of formate and retinoate (cytosol to extracellular)
unspecific monooxygenase (retinoate)

Catalysed by ESD, SLC16A4, SLC16A5, CYP1A1 and 24 morecytosol, extracellular spaceOne of 2 routes

a phenyl acetateReach from here →

S-Formylglutathione hydrolase
transport of acetate and formate (cytosol to extracellular)
a phenyl acetate + H2O = a phenol + acetate + H(+)

Catalysed by ESD, SLC16A4, SLC16A5, SLC16A1 and 3 morecytosol, extracellular space

an organic moleculeReach from here →

S-formylglutathione + H2O = formate + glutathione + H(+)
a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ESD, CP, PRDX6, CYP2D7 and 24 more

N-octanoyl-(2S)-hydroxyglycineReach from here →

S-formylglutathione + H2O = formate + glutathione + H(+)
L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by ESD, CLIC1, GSTO1, GSTO2 and 1 more

N-decanoyl-(2S)-hydroxyglycineReach from here →

S-formylglutathione + H2O = formate + glutathione + H(+)
L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
N-decanoylglycine + 2 L-ascorbate + O2 = N-decanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by ESD, CLIC1, GSTO1, GSTO2 and 1 more