malonaldehyde

Three steps

• 15-oxoprostaglandin D2Reach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. prostaglandin-D synthase (prostaglandin H2)
  3. 15-dehydro-prostaglandin D2 reduction

  Catalysed by TBXAS1, HPGDS, PTGDScytosolOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by TBXAS1, SLCO2A1, GPX5, GPX1 and 7 morecytosol, extracellular space

• leukotriene A4Reach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of prostaglandin H2 (cytosol to extracellular)
  3. transport of leukotriene A4 (cytosol to extracellular)

  Catalysed by TBXAS1, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• (R)-S-lactoylglutathioneReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by TBXAS1, SLCO2A1, GLO1, GLOD4cytosol, extracellular spaceOne of 2 routes

• S-formylglutathioneReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by TBXAS1, SLCO2A1, ADH1C, ADH1A and 4 morecytosol, extracellular space

• dehydroepiandrosterone 3-sulfateReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of prostaglandin H2 (cytosol to extracellular)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by TBXAS1, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• leukotriene C4Reach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of prostaglandin H2 (cytosol to extracellular)
  3. transport of leukotriene C4 (cytosol to extracellular)

  Catalysed by TBXAS1, SLCO1B1cytosol, extracellular spaceOne of 6 routes

• glutathione disulfideReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by TBXAS1, SLCO2A1, GPX5, GPX1 and 7 morecytosol, extracellular spaceOne of 13 routes

• taurolithocholate 3-sulfateReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of prostaglandin H2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by TBXAS1, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• histamineReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of prostaglandin H2 (cytosol to extracellular)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by TBXAS1, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• L-thyroxineReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of prostaglandin H2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by TBXAS1, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• S-sulfanylglutathioneReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by TBXAS1, SLCO2A1, SQORcytosol, extracellular space, mitochondrial matrix

• dopamineReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of prostaglandin H2 (cytosol to extracellular)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by TBXAS1, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• (2S)-2-phospholactateReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by TBXAS1, SLCO2A1, PGPcytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of prostaglandin H2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by TBXAS1, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• estrone 3-sulfateReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of prostaglandin H2 (cytosol to extracellular)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by TBXAS1, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• L-cysteinylglycineReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by TBXAS1, SLCO2A1, GGTLC3, GGT1 and 4 morecytosol, extracellular spaceOne of 4 routes

• (R)-noradrenalineReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of prostaglandin H2 (cytosol to extracellular)
  3. transport of noradrenaline (cytosol to extracellular)

  Catalysed by TBXAS1, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of prostaglandin H2 (cytosol to extracellular)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5

  Catalysed by TBXAS1, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• ursodeoxycholateReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of prostaglandin H2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by TBXAS1, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• prostaglandin G2Reach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of prostaglandin H2 (cytosol to extracellular)
  3. transport of prostaglandin G2 (cytosol to extracellular)

  Catalysed by TBXAS1, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• 11beta-prostaglandin F2Reach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. prostaglandin-D synthase (prostaglandin H2)
  3. prostaglandin D2 + NADPH + H(+) = 11beta-prostaglandin F2 + NADP(+)

  Catalysed by TBXAS1, HPGDS, PTGDS, AKR1C3 and 1 morecytosol

• thromboxane B2Reach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. thromboxane A synthase (prostaglandin H2)
  3. thromboxane A2 hydrolysis

  Catalysed by TBXAS1cytosol, endoplasmic reticulumOne of 8 routes

• taurochenodeoxycholateReach from here →
  1. thromboxane A synthase (12(S)-HHT)
  2. transport of prostaglandin H2 (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by TBXAS1, SLCO1B1, SLCO1A2, SLC7A9 and 1 morecytosol, extracellular spaceOne of 4 routes