fatty acid
362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API
739 compounds within 3 steps: 26 in 1, 174 in 2, 539 in 3
Three steps
- (10Z)-heptadecenoic acid formation
- long-chain-fatty-acid-CoA ligase (stearate)
- heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosol
- (10Z)-heptadecenoic acid formation
- (9E)-octadecenoyl-CoA hydrolase
- Acetyl-CoA:arylamine N-acetyltransferase
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 moreextracellular space, cytosol
- (10Z)-heptadecenoic acid formation
- (9E)-octadecenoyl-CoA hydrolase
- N1,N12-diacetylspermine to N1-acetylspermine conversion
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 moreextracellular space, cytosolOne of 2 routes
- N-acylsphingosine amidohydrolase
- an N-acylsphinganine + H2O = sphinganine + a fatty acid
- a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 2 morecytosolOne of 9 routes
- (10Z)-heptadecenoic acid formation
- acyl-CoA pool formation and breakdown
- Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1extracellular space, cytosol
- (10Z)-heptadecenoic acid formation
- Utilized Transport
- palmitoyl-CoA:L-carnitine O-palmitoyltransferase
Catalysed by CPT2, CPT1Aextracellular space, endoplasmic reticulum, cytosol, peroxisomeOne of 14 routes
- (10Z)-heptadecenoic acid formation
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
- A + NADH + H(+) = AH2 + NAD(+)
Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1extracellular spaceOne of 19 routes
- (10Z)-heptadecenoic acid formation
- transport of arachidonate and GSH (cytosol to extracellular)
- cystine to cysteine conversion
No catalyst recordedextracellular space, cytosolOne of 3 routes
- N-acylsphingosine amidohydrolase
- delta 4-desaturase, sphingolipid (dihydroceramide pool)
- ceramide:phosphatidylcholine cholinephosphotransferase
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 5 morecytosol, Golgi apparatusOne of 8 routes
- (10Z)-heptadecenoic acid formation
- (9E)-octadecenoyl-CoA hydrolase
- Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes
- (10Z)-heptadecenoic acid formation
- fatty acid amide hydrolase (2-arachidonoylglycerol)
- 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by FAAH, CES2, ABHD16A, EPHX1 and 7 moreextracellular space, cytosol
- (10Z)-heptadecenoic acid formation
- acyl-CoA pool formation and breakdown
- acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 1 moreextracellular space, cytosolOne of 2 routes
- (10Z)-heptadecenoic acid formation
- (9E)-octadecenoyl-CoA hydrolase
- N1,N8-diacetylspermidine to N1-acetylspermidine conversion
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 moreextracellular space, cytosol
Catalysed by SLC25A20extracellular space, endoplasmic reticulum, cytosol, mitochondrial matrixOne of 7 routes
- N-acylsphingosine amidohydrolase
- delta 4-desaturase, sphingolipid (dihydroceramide pool)
- UDP-glucose:N-acylsphingosine D-glucosyltransferase
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 4 morecytosolOne of 2 routes
- N-acylsphingosine amidohydrolase
- delta 4-desaturase, sphingolipid (dihydroceramide pool)
- an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 4 morecytosolOne of 2 routes
- (10Z)-heptadecenoic acid formation
- 11-peroxy-docosahexaenoate to DHA conversion
- 11-peroxy-docosahexaenoate to DHA conversion
No catalyst recordedextracellular space, cytosol
- (10Z)-heptadecenoic acid formation
- 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)
- 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)
Catalysed by ABHD11extracellular space
- (10Z)-heptadecenoic acid formation
- long-chain-fatty-acid-CoA ligase (EPA)
- (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoA + H2O2
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 moreextracellular space, cytosol
- N-acylsphingosine amidohydrolase
- delta 4-desaturase, sphingolipid (dihydroceramide pool)
- a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 5 morecytosolOne of 2 routes
- (10Z)-heptadecenoic acid formation
- N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate
- N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + UDP + H(+)
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 2 moreextracellular space
- (10Z)-heptadecenoic acid formation
- long-chain-fatty-acid-CoA ligase (stearate)
- a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosol
- (10Z)-heptadecenoic acid formation
- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate
- (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O
- (10Z)-heptadecenoic acid formation
- long-chain-fatty-acid-CoA ligase (eicosanoate)
- eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 moreextracellular space, cytosol
- (10Z)-heptadecenoic acid formation
- (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
- 3-octadecanoyl-sn-glycerol + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 5 moreextracellular space
- (10Z)-heptadecenoic acid formation
- (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
- 1-octanoylglycerol + (9Z)-octadecenoyl-CoA = 1-octanoyl-3-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 5 moreextracellular space
- (10Z)-heptadecenoic acid formation
- (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
- 1-dodecanoylglycerol + (9Z)-octadecenoyl-CoA = 1-dodecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 6 moreextracellular space
- (10Z)-heptadecenoic acid formation
- (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
- 1-octadecanoylglycerol + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 6 moreextracellular space
- (10Z)-heptadecenoic acid formation
- (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
- 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-(9Z,12Z,15Z-octadecatrienoyl)-3-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 6 moreextracellular space
- (10Z)-heptadecenoic acid formation
- (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
- 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-3-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 5 moreextracellular space
- (10Z)-heptadecenoic acid formation
- (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
- 1-tetradecanoylglycerol + (9Z)-octadecenoyl-CoA = 1-tetradecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 5 moreextracellular space
- (10Z)-heptadecenoic acid formation
- (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
- 1-O-(9Z-octadecenyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 10 moreextracellular space
- (10Z)-heptadecenoic acid formation
- (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
- 1-decanoylglycerol + (9Z)-octadecenoyl-CoA = 1-decanoyl-3-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 5 moreextracellular space
- N-acylsphingosine amidohydrolase
- delta 4-desaturase, sphingolipid (dihydroceramide pool)
- an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 4 morecytosolOne of 2 routes
- (10Z)-heptadecenoic acid formation
- 1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+)
- 1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+)
Catalysed by DAGLBextracellular space
- (10Z)-heptadecenoic acid formation
- (9E)-octadecenoyl-CoA hydrolase
- acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes
- (10Z)-heptadecenoic acid formation
- arachidonic acid:oxygen 1-oxidoreductase
- 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP + H(+)
Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 26 moreextracellular space, cytosol
- (10Z)-heptadecenoic acid formation
- (9E)-octadecenoyl-CoA hydrolase
- long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 moreextracellular space, cytosolOne of 6 routes
- (10Z)-heptadecenoic acid formation
- 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)
- 2 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + sn-glycero-3-phospho-(1'-sn-glycerol)
- (10Z)-heptadecenoic acid formation
- (9E)-octadecenoyl-CoA hydrolase
- long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 moreextracellular space, cytosolOne of 11 routes
- (10Z)-heptadecenoic acid formation
- (9E)-octadecenoyl-CoA hydrolase
- Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes
- (10Z)-heptadecenoic acid formation
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O2
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 moreextracellular space
- (10Z)-heptadecenoic acid formation
- Long-Chain-Fatty-Acid-Coa Ligase
- (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 moreextracellular space, endoplasmic reticulumOne of 2 routes
- (10Z)-heptadecenoic acid formation
- (9E)-octadecenoyl-CoA hydrolase
- Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes
- (10Z)-heptadecenoic acid formation
- (9E)-octadecenoyl-CoA hydrolase
- Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes
- (10Z)-heptadecenoic acid formation
- (9E)-octadecenoyl-CoA hydrolase
- Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes