fatty acid

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

739 compounds within 3 steps: 26 in 1, 174 in 2, 539 in 3

Two steps

12-hydroxydodecanoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. alkane 1-monooxygenase (lauric acid)
Catalysed by CYP4A11, CYP4A22extracellular space, cytosolOne of 2 routes
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
1. (10Z)-heptadecenoic acid formation
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
Catalysed by FAAHextracellular space, cytosol
an N-acylsphing-4-enineReach from here →
1. N-acylsphingosine amidohydrolase
2. delta 4-desaturase, sphingolipid (dihydroceramide pool)
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 3 morecytosolOne of 5 routes
1,2,3-tri-(9Z-octadecenoyl)-glycerolReach from here →
1. (10Z)-heptadecenoic acid formation
2. 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
Catalysed by DGAT1, LIPA, PNPLA4, LIPE and 1 moreextracellular space
16-hydroxyhexadecanoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum
Catalysed by CYP4F2, CYP4F3extracellular space, endoplasmic reticulumOne of 2 routes
(6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. Long-Chain-Fatty-Acid-Coa Ligase
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 3 moreextracellular space, endoplasmic reticulum
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 moreextracellular space
dodecanoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (lauric acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 3 routes
eicosanoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 6 routes
(9Z,12Z)-octadecadienoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (linoleate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 5 routes
tetradecanoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (myristic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 4 routes
(9Z)-octadecenoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 4 moreextracellular space
octadecanoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (stearate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 3 moreextracellular space, cytosolOne of 6 routes
prostaglandin H2Reach from here →
1. (10Z)-heptadecenoic acid formation
2. prostaglandin-endoperoxide synthase (arachidonate)
Catalysed by PTGS1, PTGS2extracellular space, cytosolOne of 3 routes
(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
Catalysed by ALOX5, ALOX15, ALOX12extracellular space
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
Catalysed by ALOX15B, ALOX15, ALOX12extracellular space
(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
Catalysed by ALOX5extracellular space
leukotriene A4Reach from here →
1. (10Z)-heptadecenoic acid formation
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O
Catalysed by ALOX5extracellular space
(13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. Linoleate:oxygen 13-oxidoreductase
Catalysed by ALOX15B, ALOX15extracellular space, cytosol
(R)-2-hydroxyoctadecanoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. octadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O
Catalysed by FA2Hextracellular space
sphinganineReach from here →
1. N-acylsphingosine amidohydrolase
2. an N-acylsphinganine + H2O = sphinganine + a fatty acid
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosol
an acyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. acyl-CoA pool formation and breakdown
No catalyst recordedextracellular space, cytosol
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
1. (10Z)-heptadecenoic acid formation
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
Catalysed by FAAH, PM20D1extracellular space
(9S)-hydroperoxy-(10E,12Z)-octadecadienoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. linoleate:oxygen 9-oxidoreductase
No catalyst recordedextracellular space, cytosol
(2E)-hexadecenoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. Long-Chain-Fatty-Acid-Coa Ligase
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 3 moreextracellular space, endoplasmic reticulumOne of 2 routes
(9Z)-hexadecenoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (palmitolate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 5 routes
CHEBI:63544Reach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (adrenic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 2 routes
18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. cytochrome P450 (arachidonate)
Catalysed by CYP4F8extracellular space, endoplasmic reticulumOne of 2 routes
hexacosanoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (cerotic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 3 routes
tetracosanoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (lignocerate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 6 routes
docosanoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (behenic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 4 routes
an N-acylsphinganine-1-phosphocholineReach from here →
1. N-acylsphingosine amidohydrolase
2. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 3 morecytosol
(2E)-octadecenoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. fatty-acid-CoA ligase
Catalysed by ACSL1extracellular space, cytosol
1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. (10Z)-heptadecenoic acid formation
2. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)
Catalysed by ABHD12extracellular space
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. (10Z)-heptadecenoic acid formation
2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)
Catalysed by ABHD16Aextracellular space
N-dodecanoylsphing-4-enineReach from here →
1. (10Z)-heptadecenoic acid formation
2. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine
Catalysed by NAAA, ASAH1, ACER2, ASAH2extracellular space
N-tetradecanoylsphing-4-enineReach from here →
1. (10Z)-heptadecenoic acid formation
2. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate
Catalysed by ASAH1, ACER2, ASAH2extracellular space
N-octadecanoylsphing-4-enineReach from here →
1. (10Z)-heptadecenoic acid formation
2. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
Catalysed by ASAH1, ACER2, ASAH2extracellular space
(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. (7Z,10Z,13Z,16Z)-docosatetraenoate + ATP + CoA = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AMP + diphosphate
Catalysed by ACSL4extracellular space
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (EPA)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 3 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (DPA)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 2 routes
(9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (linolenate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 2 routes
(11Z)-eicosenoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 2 routes
(15Z)-tetracosenoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (nervonic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 2 routes
(17Z)-hexacosenoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (ximenic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 2 routes
(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 2 routes
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. long-chain-fatty-acid-CoA ligase (DHA)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moreextracellular space, cytosolOne of 3 routes
N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
1. (10Z)-heptadecenoic acid formation
2. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine
Catalysed by ACER2, ACER1, ASAH2extracellular space
(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
Catalysed by ALOX12Bextracellular space
(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. Arachidonate:oxygen 8-oxidoreductase
Catalysed by ALOX12extracellular space, cytosolOne of 2 routes