Catalyst

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Search ?

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

Reach

(5Z,8Z,11Z,14Z)-eicosatetraenoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

735 compounds within 3 steps: 59 in 1, 173 in 2, 503 in 3

Does it reach a compound?

One step

(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CYP2C9
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. unspecific monooxygenase (arachidonate)
Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 23 morecytosolOne of 4 routes
8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →
1. unspecific monooxygenase (arachidonate)
Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 22 morecytosolOne of 3 routes
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserineReach from here →
1. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoserine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by ABHD16A
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by ABHD16A
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by ABHD16A
(18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CYP4F8
15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
Catalysed by ALOX15B
5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
Catalysed by ALOX15B

Two steps

CHEBI:1146900Reach from here →
1. Arachidonate:CoA ligase (AMP-forming)
2. Arachidonyl-CoA hydrolase
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 9 morecytosolOne of 255 routes
(5E)-tetradecenoyl-(R)-carnitineReach from here →
1. Utilized Transport
2. carnitine O-palmitoyltransferase ((9E)-tetradecenoyl-CoA)
Catalysed by CPT1A, CPT1C, CPT1Bendoplasmic reticulum, cytosolOne of 7 routes

Page 2 of 15

tauroursodeoxycholateReach from here →

transport of arachidonate (cytosol to extracellular)
transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

glycoursodeoxycholateReach from here →

transport of arachidonate (cytosol to extracellular)
transport of glycoursodeoxycholate (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

(14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O

Catalysed by ALOX15B, ALOX15, ALOX12

N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycineReach from here →

N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine

Catalysed by FAAH, PM20D1, ALOX15, ALOX12

N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycineReach from here →

N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine

Catalysed by FAAH, PM20D1, ALOX15B, ALOX15 and 1 more

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

arachidonate:oxygen 15-oxidoreductase
palmitoyl-CoA hydrolase (15(S)-HPETE)

Catalysed by ALOX15B, ALOX15cytosol

(8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoateReach from here →

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate

Catalysed by ALOX5, ALOX15, ALOX12

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
glutathione transferase (GSH)

Catalysed by PTGES, MGST3, GSTA4, GSTZ1 and 17 moreextracellular space, cytosolOne of 4 routes

prostaglandin E3Reach from here →

transport of arachidonate (cytosol to extracellular)
transport of prostaglandin E3 (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

prostaglandin A2Reach from here →

transport of arachidonate (cytosol to extracellular)
transport of prostaglandin A2 (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

prostaglandin B1Reach from here →

transport of arachidonate (cytosol to extracellular)
transport of prostaglandin B1 (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →

(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 more

leukotriene F4Reach from here →

transport of arachidonate (cytosol to extracellular)
transport of leukotriene F4 (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →

unspecific monooxygenase (arachidonate)
8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate

Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 23 morecytosol

11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoAReach from here →

(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate

Catalysed by CYP2C9, ACSL4, ACSL3, ACSL5

14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoAReach from here →

unspecific monooxygenase (arachidonate)
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate

Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 27 morecytosol

5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →

unspecific monooxygenase (arachidonate)
5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate

Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 23 morecytosol

2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerolReach from here →

fatty acid amide hydrolase (2-arachidonoylglycerol)
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol

Catalysed by FAAH, ALOX15Bcytosol

(13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate

Catalysed by ALOX15B, ALOX15, ALOX12, CYP2J2

(5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Catalysed by ALOX5, ALOX15B

2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerolReach from here →

fatty acid amide hydrolase (2-arachidonoylglycerol)
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol

Catalysed by FAAH, ALOX15Bcytosol

1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineReach from here →

(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 more

(15S)-15-hydroperoxy-prostaglandin E2Reach from here →

Arachidonate:oxygen oxidoreductase
prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2

Catalysed by PTGS1, PTGS2, PTGESendoplasmic reticulum

acetylcholineReach from here →

transport of arachidonate (cytosol to extracellular)
transport of acetylcholine (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1B3extracellular space, cytosolOne of 4 routes

propionyl-CoAReach from here →

Utilized Transport
Active Transport

No catalyst recordedendoplasmic reticulum, cytosol, mitochondrial matrixOne of 2 routes

CHEBI:15650Reach from here →

transport of arachidonate (cytosol to extracellular)
transport of leukotriene E4 (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheineReach from here →

(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 more

betaine aldehydeReach from here →

(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
choline + A = betaine aldehyde + AH2

Catalysed by PTGS1, PTGS2, CHDH

hexadecanoic acidReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation

No catalyst recordedcytosol, extracellular spaceOne of 14 routes

bromideReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

Catalysed by MGST3, GSTA4, GSTA1, GSTA2 and 13 moreextracellular space, cytosolOne of 2 routes

lithocholic acidReach from here →

transport of arachidonate (cytosol to extracellular)
transport of lithocholate (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

oxaloacetateReach from here →

(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
(R)-malate + A = oxaloacetate + AH2

Catalysed by PTGS1, PTGS2, D2HGDH

(S)-lactateReach from here →

prostaglandin-endoperoxide synthase (arachidonate)
prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)

Catalysed by PTGS1, PTGS2, SLCO2A1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

formaldehydeReach from here →

(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2

Catalysed by PTGS1, PTGS2, KDM1A, KDM1BOne of 3 routes

bilirubin IXalphaReach from here →

transport of arachidonate (cytosol to extracellular)
transport of bilirubin (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

taurolithocholateReach from here →

transport of arachidonate (cytosol to extracellular)
transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

CHEBI:17208Reach from here →

transport of arachidonate and GSH (cytosol to extracellular)
glutathione:dehydroascorbate oxidoreductase

No catalyst recordedextracellular space, cytosol

homocysteineReach from here →

transport of arachidonate and GSH (cytosol to extracellular)
Formation of Homocystine

No catalyst recordedextracellular space, cytosol

all-trans-retinolReach from here →

(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

Catalysed by PTGS1, PTGS2, RETSAT