1-O-acyl-sn-glycero-3-phosphocholine(1+)

Two steps

• alpha-linolenic acidReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• CHEBI:27540Reach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 6 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 17 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• CHEBI:28701Reach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosol, peroxisomeOne of 7 routes

• phosphocholineReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 7 morecytosol

• tetradecanoateReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• (9Z)-octadecenoateReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• hexacosanoateReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• tetracosanoateReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• an N-acylsphinganineReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. N-acylsphingosine amidohydrolase

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 11 morecytosol

• eicosanoateReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• (9Z)-hexadecenoateReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• (15Z)-tetracosenoateReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• (11Z)-eicosenoateReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• taurineReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosolOne of 2 routes

• glycineReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 2 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 6 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. Production of Glutaryl Carnitine

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. phytanate-CoA ligase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 7 morecytosolOne of 15 routes

• sn-glycerol 3-phosphateReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 8 morecytosol

• sphing-4-enineReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 4 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 2 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosol, mitochondrial matrix

• L-alanineReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosol, mitochondrial matrix

• glycerol 2-phosphateReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. Glycerophosphocholine Phosphodiesterase

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 7 morecytosol

• L,L-cystathionineReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 1 morecytosol, mitochondrial matrix

• an acyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 4 morecytosol, Golgi apparatusOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosol, mitochondrial matrixOne of 3 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  2. (10Z)-heptadecenoic acid formation

  Catalysed by LYPLA1, LYPLA2, PLA2G4A, PLB1 and 6 morecytosol, extracellular spaceOne of 12 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 2 morecytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 2 morecytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 6 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 3 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 8 morecytosolOne of 11 routes