1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine

Three steps

• isovaleryl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 morecytosolOne of 14 routes

• CHEBI:15519Reach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 morecytosolOne of 14 routes

• oleoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosolOne of 14 routes

• phenylacetyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 morecytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosolOne of 43 routes

• (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• 12(S)-HPETEReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular spaceOne of 4 routes

• 15(S)-HPETEReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. arachidonate:oxygen 15-oxidoreductase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 morecytosol, extracellular spaceOne of 4 routes

• 5(S)-HPETEReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• CHEBI:15650Reach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 47 morecytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosol

• CHEBI:15746Reach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 20 morecytosolOne of 2 routes

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. ethanolaminephosphotransferase (1-alkenyl-2-acylglycerol)
  2. CDPethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase
  3. Phosphatidylethanolamine N-Methyltransferase

  Catalysed by SELENOI, CEPT1, PEMTcytosol, mitochondrial matrixOne of 2 routes

• CHEBI:16132Reach from here →
  1. phospholipase D (O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine)
  2. ethanolamine ammonia-lyase (acetaldehyde-forming)
  3. deoxyribose-phosphate aldolase

  Catalysed by PLD2, PLD1, DERAcytosol

• 11-cis-retinyl hexadecanoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 11-peroxy-docosahexaenoate to DHA conversion

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 14 morecytosol, extracellular spaceOne of 3 routes

• 11-cis-retinolReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 23 morecytosol

• phosphatidic acidReach from here →
  1. ethanolaminephosphotransferase (1-alkenyl-2-acylglycerol)
  2. CDPethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase
  3. phosphatidylethanolamine phosphatidohydrolase

  Catalysed by SELENOI, CEPT1, PLD2, PLD1cytosol

• oxaloacetateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosol

• CHEBI:16566Reach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. N-acylsphingosine amidohydrolase
  3. N-acylsphingosine amidohydrolase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosol

• 8-hydroxydodecanoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 8-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• 10-hydroxydodecanoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• 9-hydroxydodecanoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 9-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• 9-hydroxytetradecanoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. tetradecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 9-hydroxytetradecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• 10-hydroxytetradecanoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. tetradecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxytetradecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• 12-hydroxytetradecanoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. tetradecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 12-hydroxytetradecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• 11-hydroxytetradecanoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. tetradecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 11-hydroxytetradecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• CHEBI:16856Reach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 14 morecytosol, extracellular spaceOne of 2 routes

• octadecanalReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• anilineReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 20 morecytosol

• CHEBI:17312Reach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 morecytosolOne of 2 routes

• L-cysteineReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosol, mitochondrial matrix

• hexadecanalReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 2 H+[c] + NADH[c] + palmitate[c] = H2O[c] + hexadecanal[c] + NAD+[c]

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 morecytosol, extracellular spaceOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycerolReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. N-acylsphingosine amidohydrolase
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosolOne of 23 routes

• CHEBI:17927Reach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 morecytosol

• phosphatidyl-L-serineReach from here →
  1. ethanolaminephosphotransferase (1-alkenyl-2-acylglycerol)
  2. CDPethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase
  3. L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase

  Catalysed by SELENOI, CEPT1, PTDSS2cytosol

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• (5Z)-dodecenoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, mitochondrial matrixOne of 2 routes

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 20 morecytosol, extracellular space

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 morecytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 morecytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 24 morecytosolOne of 6 routes

• dodecanalReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 2 H+[r] + lauric acid[r] + NADH[r] = H2O[r] + NAD+[r] + dodecanal[r]

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space, endoplasmic reticulumOne of 3 routes