all-trans-retinol

Three steps

• deoxycholoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 3 morecytosolOne of 4 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by RETSAT, MOCOS, PPCScytosolOne of 4 routes

• 3-sulfino-L-alanineReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by RETSAT, MOCOS, CDO1cytosolOne of 2 routes

• decanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 7 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 4 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 3 morecytosol

• CHEBI:63544Reach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 7 routes

• hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
  2. 2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)

  Catalysed by LRAT, ASPG, PLAAT3, PLAAT1One of 2 routes

• hexacosanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 9 routes

• a 2,3-saturated acyl-CoAReach from here →
  1. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by RETSAT, AIFM1, PYROXD1, ACAD10One of 2 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 4 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 8 routes

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. Lecithin Retinol Acyltransferase
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LRAT, LYPLA1, LYPLA2, PLA2G4A and 7 morecytosol, extracellular spaceOne of 12 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
  2. di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)

  Catalysed by PNPLA4, PNPLA2, DDHD2, PNLIPRP2 and 1 more

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
  2. di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)

  Catalysed by PNPLA4, PNPLA2, DDHD2, PNLIPRP2 and 1 more

• 1,2-dihexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
  2. 2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)

  Catalysed by LRAT, ASPG, PLD2, PLD1

• N-hexadecanoylsphing-4-enineReach from here →
  1. all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
  2. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  3. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate

  Catalysed by DGAT1, PNPLA4, AWAT2, MOGAT3 and 7 more

• 1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
  2. 2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

  Catalysed by LRAT, ASPG, PLA2G10, PLA2G6 and 12 moreOne of 3 routes

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
  1. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
  2. 2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
  3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by LRAT, ASPG, TAFAZZIN

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 5 routes

• nonadecanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 4 morecytosolOne of 3 routes

• (R)-2-hydroxyhexadecanoateReach from here →
  1. all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
  2. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  3. hexadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O

  Catalysed by DGAT1, PNPLA4, AWAT2, MOGAT3 and 4 more

• dodecanedioyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Activation of dodecanedioic acid

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 1 morecytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Production of Sebacoylcarnitine

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 4 morecytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Production of Suberylcarnitine

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 4 morecytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 1 morecytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 5 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 4 morecytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 9 morecytosolOne of 5 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 3 morecytosol, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. Lecithin Retinol Acyltransferase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by LRAT, LPCAT4, LPCAT3, LPCAT2 and 5 morecytosol, peroxisome