1-acyl-sn-glycerol 3-phosphate

Three steps

• L-citrullineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 11 moremitochondrial matrix, extracellular space, cytosolOne of 8 routes

• L-valineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 moremitochondrial matrix, extracellular space, cytosolOne of 20 routes

• L-arginineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 moremitochondrial matrix, extracellular space, cytosolOne of 18 routes

• CHEBI:16523Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 10 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. PROTEIN_BS

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 moremitochondrial matrix, cytosolOne of 5 routes

• CHEBI:16633Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 moremitochondrial matrix, cytosol

• Met-tRNA(Met)Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 moremitochondrial matrix, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 moremitochondrial matrix

• 2-oxobutanoateReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
  3. L-cystathionine cysteine-lyase (deaminating

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:16856Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 37 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• CHEBI:16857Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 11 moremitochondrial matrix, extracellular space, cytosolOne of 19 routes

• pantetheine 4'-phosphateReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. acid phosphatase 2, lysosomal (CoA)
  3. Dephospho-CoA nucleotidohydrolase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 moremitochondrial matrix, lysosome, cytosolOne of 2 routes

• psychosineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 moremitochondrial matrix, Golgi apparatus, cytosol

• glyoxylic acidReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 moremitochondrial matrix, peroxisome

• a cholesterol esterReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 11 moremitochondrial matrix, Golgi apparatus

• taurolithocholateReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 moremitochondrial matrix, cytosolOne of 2 routes

• L-isoleucineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 moremitochondrial matrix, extracellular space, cytosolOne of 18 routes

• CHEBI:17203Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 10 moremitochondrial matrix, extracellular space, cytosolOne of 15 routes

• S-(4,8-dimethylnonanoyl)-4'-phosphopantetheineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
  3. 4,8-dimethylnonanoyl-CoA + H2O = S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 moremitochondrial matrix, peroxisome

• S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (linolenate)
  3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 14 moremitochondrial matrix, cytosol

• S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 14 moremitochondrial matrix, cytosol

• S-(9Z-hexadecenoyl)-4'-phosphopantetheineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 14 moremitochondrial matrix, cytosol

• itaconateReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Itaconate:CoA ligase (GDP-forming)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 moremitochondrial matrixOne of 4 routes

• N-octadecanoyl-heptadecasphing-4-enineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosol

• all-trans-retinolReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-Retinol 11-cis-trans-isomerase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 10 moremitochondrial matrix, cytosolOne of 2 routes

• linoleic acidReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 15 routes

• a 2-acylglycerolReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  3. a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 10 moremitochondrial matrix, nucleus

• a monoacylglycerolReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  3. 1,2-diacyl-sn-glycerol acylhydrolase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 22 moremitochondrial matrix, nucleus, extracellular spaceOne of 8 routes

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, Golgi apparatus, cytosol

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 moremitochondrial matrix, cytosol, peroxisomeOne of 14 routes

• AH2Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 moremitochondrial matrix, cytosolOne of 6 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Lecithin Retinol Acyltransferase (11-Cis)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 10 moremitochondrial matrix, cytosol

• S-methyl-5'-thioadenosineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. S-adenosylmethioninamine:spermidine 3-aminopropyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 moremitochondrial matrix, cytosolOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 11 moremitochondrial matrixOne of 2 routes

• hexadecanalReach from here →
  1. 1-acylglycerol-3-phosphate pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  3. hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O

  Catalysed by LYPLA2, PNPLA7, PNPLA6, ALDH3B1 and 2 morecytosol

• all-trans-retinyl hexadecanoateReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 11 moremitochondrial matrix, cytosolOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 moremitochondrial matrix, cytosol

• glycerolReach from here →
  1. 1-acylglycerol-3-phosphate pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  3. sn-glycerol 3-phosphate + H2O = glycerol + phosphate

  Catalysed by LYPLA2, PNPLA7, PNPLA6, PGPcytosol

• CHEBI:17769Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. spermidine:(acceptor) oxidoreductase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 moremitochondrial matrix, cytosol

• a triacylglycerolReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 14 moremitochondrial matrix, Golgi apparatus, cytosolOne of 2 routes

• CHEBI:17895Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 moremitochondrial matrix, extracellular space, cytosolOne of 19 routes

• butanoateReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + H2O = butanoate + CoA + H(+)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 17 moremitochondrial matrix, cytosol

• CHEBI:18019Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 moremitochondrial matrix, extracellular space, cytosolOne of 10 routes

• L-glutamineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 moremitochondrial matrix, extracellular space, cytosolOne of 29 routes

• spermine monoaldehydeReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. diamine N-acetyltransferase (N1-acetylspermine)
  3. primary-amine oxidase (spermine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 10 moremitochondrial matrix, cytosolOne of 3 routes

• CHEBI:18095Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Transport of Hydroxy-Proline

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 moremitochondrial matrix, extracellular space, cytosol

• O-octanoyl-(R)-carnitineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. solute carrier (L-carnitine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 moremitochondrial matrix, cytosolOne of 11 routes

• CHEBI:18132Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. ATP:choline phosphotransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 moremitochondrial matrix, nucleus, cytosol

• dodecanoateReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. Lauroyl-CoA hydrolase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 17 moremitochondrial matrix, cytosolOne of 14 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 moremitochondrial matrix, cytosol