1-acyl-sn-glycerol 3-phosphate

Two steps

• (R)-methylmalonyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 moremitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 5 moremitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 moremitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 5 moremitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 moremitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 11 moremitochondrial matrix, cytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Production of Glutaryl Carnitine

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 moremitochondrial matrix, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 moremitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 moremitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. phytanate-CoA ligase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 12 moremitochondrial matrix, cytosolOne of 15 routes

• sn-glycerol 3-phosphateReach from here →
  1. 1-acylglycerol-3-phosphate pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)

  Catalysed by LYPLA2, PNPLA7, PNPLA6cytosol

• sphing-4-enineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 moremitochondrial matrix, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 moremitochondrial matrix, cytosolOne of 3 routes

• L-methionineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 moremitochondrial matrix

• L-alanineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 5 moremitochondrial matrix

• L-asparagineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 moremitochondrial matrix

• L,L-cystathionineReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 6 moremitochondrial matrix

• 1-hexadecanoylglycerone 3-phosphateReach from here →
  1. 1-acylglycerol-3-phosphate pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)

  Catalysed by DHRS7Bcytosol

• an acyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 9 moremitochondrial matrix, Golgi apparatusOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 moremitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 moremitochondrial matrix, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 moremitochondrial matrix, cytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 11 moremitochondrial matrix, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 moremitochondrial matrix, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 7 moremitochondrial matrix, cytosol

• CHEBI:63544Reach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 7 routes

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. 1-acylglycerol-3-phosphate pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2, GPAT3, LCLAT1, MBOAT2 and 5 morecytosol

• hexacosanoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 9 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 8 moremitochondrial matrix, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 8 routes

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. 1-acylglycerol-3-phosphate pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2cytosol

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. 1-acylglycerol-3-phosphate pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2cytosol

• 1,2-dihexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. 1-acylglycerol-3-phosphate pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2cytosol

• 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. 1-acylglycerol-3-phosphate pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2, AGPAT3cytosol

• a 1-O-alkylglycerone 3-phosphateReach from here →
  1. aldo-keto reductase (1-acylglycerol-3P pool)
  2. alkylglycerone phosphate synthase (acylglycerone-phosphate)

  Catalysed by AKR1A1, AGPScytosol, peroxisome

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 6 routes

• 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphateReach from here →
  1. 1-acylglycerol-3-phosphate pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA

  Catalysed by MBOAT2cytosol

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by AGPAT2, LCLAT1, MBOAT1, MBOAT2 and 13 moremitochondrial matrix, cytosolOne of 7 routes