CHEBI:16856

1. transport of arachidonate and GSH (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

Catalysed by ALOX12Bextracellular space, cytosol

1. transport of arachidonate and GSH (cytosol to extracellular)
2. Arachidonate:oxygen 8-oxidoreductase

Catalysed by ALOX12extracellular space, cytosolOne of 2 routes

1. transport of arachidonate and GSH (cytosol to extracellular)
2. fatty acid amide hydrolase (arachidonate)

Catalysed by FAAHextracellular space, cytosol

1. transport of arachidonate and GSH (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP2C9extracellular space, cytosol

1. transport of arachidonate and GSH (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP1A1, CYP1A2, CYP2C9, CYP2C19 and 1 moreextracellular space, cytosol

1. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
2. 10-HETE[n] + NAD+[n] = H+[n] + NADH[n] + 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate[n]

Catalysed by SLCO2A1, ADH4extracellular space, cytosol, nucleusOne of 3 routes

1. transport of GSH and ursodeoxycholate (cytosol to extracellular)
2. ursodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)

Catalysed by SLCO1A2, SLCO1B3, HSD17B10extracellular space, cytosol

1. transport of arachidonate and GSH (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O

Catalysed by PTGS2extracellular space, cytosolOne of 2 routes

1. transport of arachidonate and GSH (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

Catalysed by PTGS2extracellular space, cytosolOne of 2 routes

1. transport of arachidonate and GSH (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

Catalysed by PTGS2extracellular space, cytosol

1. transport of arachidonate and GSH (cytosol to extracellular)
2. Arachidonate: oxygen 11-oxidoreductase

Catalysed by ALOX12extracellular space, cytosolOne of 2 routes

1. cystine to cysteine conversion
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by MOCOScytosol

1. transport of arachidonate and GSH (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP2C9extracellular space, cytosol

1. transport of arachidonate and GSH (cytosol to extracellular)
2. unspecific monooxygenase (arachidonate)

Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 23 moreextracellular space, cytosolOne of 4 routes

1. transport of arachidonate and GSH (cytosol to extracellular)
2. unspecific monooxygenase (arachidonate)

Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 22 moreextracellular space, cytosolOne of 3 routes

1. transport of arachidonate and GSH (cytosol to extracellular)
2. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoserine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

Catalysed by ABHD16Aextracellular space, cytosol

1. transport of arachidonate and GSH (cytosol to extracellular)
2. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

Catalysed by ABHD16Aextracellular space, cytosol

1. transport of arachidonate and GSH (cytosol to extracellular)
2. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

Catalysed by ABHD16Aextracellular space, cytosol

1. transport of GSH and prostaglandin D2 (cytosol to extracellular)
2. prostaglandin D2 + NADPH + H(+) = 11beta-prostaglandin F2 + NADP(+)

Catalysed by SLCO2A1, AKR1C3, AKR1C2extracellular space, cytosol

1. transport of GSH and prostaglandin H2 (cytosol to extracellular)
2. prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde

Catalysed by SLCO2A1, TBXAS1, CYP2S1, PTGES2extracellular space, cytosol

1. transport of arachidonate and GSH (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP4F8extracellular space, cytosol

1. transport of GSH and prostaglandin E1 (cytosol to extracellular)
2. prostaglandin-E synthase (prostaglandin E1)

Catalysed by SLCO2A1, PTGES, PTGES3, PTGES2extracellular space, cytosolOne of 2 routes

1. transport of GSH and prostaglandin H2 (cytosol to extracellular)
2. prostaglandin H2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxyprostaglandin H2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO2A1, CYP4F8extracellular space, cytosol

1. transport of arachidonate and GSH (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

Catalysed by ALOX15Bextracellular space, cytosol

1. transport of arachidonate and GSH (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

Catalysed by ALOX15Bextracellular space, cytosol

1. cystine to cysteine conversion
2. transport of cysteine and tryptophan (cytosol to extracellular)
3. beta-carboline hydrolysis

Catalysed by SLC7A5cytosol, extracellular space

1. transport of acetylcholine and GSH (cytosol to extracellular)
2. Acetylcholine aectylhydrolase
3. transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)

Catalysed by SLCO1A2, SLCO1B3, BCHE and 4 more