CHEBI:16566

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

602 compounds within 3 steps: 3 in 1, 120 in 2, 479 in 3

Two steps

3'-dephospho-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. acid phosphatase 2, lysosomal (CoA)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 3 morecytosol, lysosomeOne of 2 routes
(2E)-dodecenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. (2E)-dodecenoyl-CoA formation
Catalysed by CERS1, CERS6, CERS3, CERS5 and 2 morecytosol, mitochondrial matrixOne of 3 routes
4,8,12-trimethyltridecanoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 morecytosol, peroxisomeOne of 2 routes
(6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 7 routes
butanoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Butanoate:CoA ligase (AMP-forming)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 8 morecytosolOne of 9 routes
dodecanoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 9 routes
glutaryl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Production of Glutaryl Carnitine
Catalysed by CERS1, CERS6, CERS3, CERS5 and 5 morecytosolOne of 2 routes
eicosanoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 12 routes
itaconyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Itaconate:CoA ligase (GDP-forming)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 5 morecytosol, mitochondrial matrixOne of 2 routes
(9Z,12Z)-octadecadienoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 13 routes
tetradecanoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (myristic acid)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 11 routes
octanoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
Catalysed by CERS1, CERS6, CERS3, CERS5 and 3 morecytosol, mitochondrial matrixOne of 20 routes
phytanoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. phytanate-CoA ligase
Catalysed by CERS1, CERS6, CERS3, CERS5 and 2 morecytosolOne of 5 routes
octadecanoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (stearate)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 9 morecytosolOne of 15 routes
sphing-4-enineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. acyl-CoA:sphingosine N-acyltransferase
Catalysed by CERS1, CERS6, CERS3, CERS5 and 6 morecytosol, Golgi apparatusOne of 2 routes
sphinganineReach from here →
1. ATP:sphinganine 1-phosphotransferase
2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
Catalysed by DBP, SPHK2, SPHK1, SGPP2 and 1 morecytosolOne of 2 routes
spermidineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. diamine N-acetyltransferase (N1-acetylspermidine)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 morecytosolOne of 3 routes
L-methionineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. N-acetylglutamate synthase (N-acetylmethionine)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 3 morecytosol, mitochondrial matrix
L-alanineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 2 morecytosol, mitochondrial matrix
L-asparagineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. N-acetylglutamate synthase (N-acetyl-L-asparagine)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 3 morecytosol, mitochondrial matrix
L,L-cystathionineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 3 morecytosol, mitochondrial matrix
phosphoethanolamineReach from here →
1. ATP:sphinganine 1-phosphotransferase
2. sphinganine 1-phosphate = hexadecanal + phosphoethanolamine
Catalysed by DBP, SPHK2, SPHK1, SGPL1cytosol
an acyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. acyl-CoA:sphingosine N-acyltransferase
Catalysed by CERS1, CERS6, CERS3, CERS5 and 6 morecytosol, Golgi apparatusOne of 2 routes
(3Z)-dodecenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 5 morecytosol, mitochondrial matrixOne of 3 routes
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 morecytosol, endoplasmic reticulumOne of 3 routes
deoxycholoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 morecytosolOne of 4 routes
decanoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. medium-chain acyl-CoA ligase (decanoic acid)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 8 morecytosolOne of 7 routes
(2E)-hexadecenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Carnitine O-Palmitoyltransferase
Catalysed by CERS1, CERS6, CERS3, CERS5 and 5 morecytosolOne of 4 routes
(9Z)-hexadecenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (palmitolate)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 11 routes
3-hydroxyisovaleryl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 morecytosol
CHEBI:63544Reach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (adrenic acid)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 7 routes
hexacosanoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (cerotic acid)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 5 routes
tetracosanoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (lignocerate)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 10 routes
docosanoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (behenic acid)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 9 routes
an N-acylsphinganine-1-phosphocholineReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 morecytosol
(2E)-octadecenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. Carnitine O-Palmitoyltransferase
Catalysed by CERS1, CERS6, CERS3, CERS5 and 5 morecytosolOne of 3 routes
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (stearidonic acid)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 8 routes
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (EPA)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 9 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (DPA)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 6 routes
(9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (linolenate)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 7 routes
(13Z)-docosenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 6 routes
(11Z)-eicosenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 7 routes
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 5 routes
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 4 routes
(15Z)-tetracosenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (nervonic acid)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 6 routes
(17Z)-hexacosenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (ximenic acid)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 4 routes
(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 5 routes
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 5 routes
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (DHA)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 7 routes
heptadecanoyl-CoAReach from here →
1. sphingosine N-acyltransferase (sphinganine)
2. long-chain-fatty-acid-CoA ligase (margaric acid)
Catalysed by CERS1, CERS6, CERS3, CERS5 and 10 morecytosolOne of 6 routes