CHEBI:15650

Three steps

• 3,3'-diiodo-L-thyronineReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DIO1 and 2 moreextracellular space, cytosolOne of 3 routes

• N-acetylserotoninReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. acetyl-CoA:aralkylamine N-acetyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, AANATextracellular space, cytosol

• CHEBI:17724Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. Formation of Homocystine
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by SLCO1B1, BHMT, BHMT2extracellular space, cytosol

• Ala-tRNA(Ala)Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix

• CHEBI:17769Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. spermidine:(acceptor) oxidoreductase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol

• urateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. glutathione:dehydroascorbate oxidoreductase
  3. ascorbate to monodehydroascorbate conversion

  Catalysed by SLCO1B1extracellular space, cytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DDCextracellular space, cytosol

• prostaglandin F1Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)
  3. prostaglandin E1 + NADPH + H(+) = prostaglandin F1 + NADP(+)

  Catalysed by SLCO1B1, SLCO2A1, DHRS1extracellular space, cytosol

• a 1,2-diacyl-sn-glycerolReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 35 morecytosol, Golgi apparatus

• a triacylglycerolReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 37 morecytosol, Golgi apparatus

• CHEBI:17895Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrix, extracellular spaceOne of 19 routes

• butanoateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + H2O = butanoate + CoA + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 40 morecytosolOne of 5 routes

• CHEBI:18019Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrix, extracellular spaceOne of 10 routes

• L-glutamineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrix, extracellular spaceOne of 29 routes

• spermine monoaldehydeReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. diamine N-acetyltransferase (N1-acetylspermine)
  3. primary-amine oxidase (spermine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosolOne of 3 routes

• (R)-3,4-dihydroxymandelaldehydeReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, MAOA and 1 moreextracellular space, cytosol

• CHEBI:18095Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Transport of Hydroxy-Proline

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix, extracellular space

• O-octanoyl-(R)-carnitineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Carnitine O-Palmitoyltransferase
  3. solute carrier (L-carnitine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrixOne of 11 routes

• CHEBI:18132Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Acetyl-CoA:choline O-acetyltransferase
  3. ATP:choline phosphotransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, nucleus

• CHEBI:18183Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. gamma-glutamyltransferase (alanine)
  3. gamma-glutamylcyclotransferase ((5-L-glutamyl)-L-amino acid)

  Catalysed by SLCO1B1, GGT1, GGT5, GGTLC2 and 5 moreextracellular space, cytosol

• dodecanoateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. Lauroyl-CoA hydrolase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 40 morecytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrix

• N-(4-aminobutyl)-3-aminopropanalReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. primary-amine oxidase (spermidine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosolOne of 3 routes

• (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (EPA)
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoA + H2O2

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 37 morecytosol

• (R)-normetanephrineReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, COMT and 1 moreextracellular space, cytosol

• 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosol

• ophthalmateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrix

• S-methylmercury-L-cysteineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-aminoisobutanoateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 11-cis-retinyl esterReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. ATP citrate lyase (citrate)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrixOne of 2 routes

• 1-butanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Butanoate:CoA ligase (AMP-forming)
  3. 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosol

• 1-octanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrix

• 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 38 morecytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrixOne of 3 routes

• O-butanoyl-(R)-carnitineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 35 morecytosol

• S-disulfanyl-L-cysteineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol, mitochondrial matrix

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by SLCO1B1, UGT1A9, UGT2B7, UGT1A6 and 3 moreextracellular space, cytosol

• 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
  3. 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP + H(+)

  Catalysed by SLCO1B1, SLCO2A1, UGT2B7, UGT1A1 and 1 moreextracellular space, cytosol

• 15-O-(beta-D-glucuronosyl)-prostaglandin B1Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin B1 (cytosol to extracellular)
  3. prostaglandin B1 + UDP-alpha-D-glucuronate = 15-O-(beta-D-glucuronosyl)-prostaglandin B1 + UDP + H(+)

  Catalysed by SLCO1B1, SLCO2A1, UGT1A9, UGT2B7 and 2 moreextracellular space, cytosol

• 3-oxo-(9Z)-eicosenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  3. very-long-chain 3-oxoacyl-CoA synthase ((7Z)-octadecenoyl-CoA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 38 morecytosol

• serotonin O-sulfateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. serotonin + 3'-phosphoadenylyl sulfate = serotonin O-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 1 moreextracellular space, cytosol

• (R)-noradrenaline 4'-O-sulfateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. sulfotransferase (noradrenaline)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3extracellular space, cytosolOne of 2 routes

• L-homocysteine thiolactoneReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. Formation of Homocystine
  3. arylesterase (homocysteine-thiolactone)

  Catalysed by SLCO1B1, PON1, PON2, PON3extracellular space, cytosol

• (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 39 morecytosolOne of 2 routes

• (2E,7Z,10Z)-hexadecatrienoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial
  3. (7Z,10Z)-hexadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z)-hexadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosol, mitochondrial matrix

• (2E,4Z,7Z,10Z,13Z)-hexadecapentaenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial
  3. Fatty Acid Beta Oxidation (C16:4->C16:5), Mitochondrial

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 4 routes

• (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial
  3. (7Z,10Z,13Z)-hexadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosol, mitochondrial matrix

• (2E,4Z,7Z)-decatrienoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial
  3. Fatty Acid Beta Oxidation (C10:2->C10:3), Mitochondrial

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrixOne of 3 routes