CHEBI:15650

Two steps

• an acyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, Golgi apparatusOne of 2 routes

• histamineReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-thyroxineReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosolOne of 4 routes

• S-sulfanylglutathioneReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by SLCO1B1, SQORextracellular space, cytosol, mitochondrial matrix

• dopamineReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycolithocholate 3-sulfateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• estrone 3-sulfateReach from here →
  1. transport of leukotriene E4 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by SLCO1B1extracellular space, cytosolOne of 2 routes

• prostaglandin E2Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 34 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Carnitine O-Palmitoyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 11 routes

• L-cysteinylglycineReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. glutathione gamma-glutamylaminopeptidase

  Catalysed by SLCO1B1, GGTLC3, GGT1, GGT5 and 3 moreextracellular space, cytosolOne of 4 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol

• CHEBI:63544Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 9 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Carnitine O-Palmitoyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 8 routes

• (R)-noradrenalineReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• nonadecanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 3 routes

• dodecanedioyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Activation of dodecanedioic acid

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 28 morecytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Production of Sebacoylcarnitine

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Production of Suberylcarnitine

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 28 morecytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol, peroxisomeOne of 3 routes