Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:O94777

DPM2

Protein·UNIPROT:O94777

Open in the graph

Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the GPI-GNT complex..

Function from UniProtKB (O94777), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

congenital muscular dystrophy with intellectual disability and severe epilepsy has a germline basis in DPM2DiseaseGenCC HGNC:3006|MONDO:0014023Inferred only

Statements

42 statements

42 statements · 3 reference databases · Subject: DPM2 · Sources: Hetionet, Reactome, WikiPathways

Search this listOrder

DPM2 covaries with CACYBPProteinHetionet hetionet:covaries:27101-8818Inferred only
DPM2 covaries with PIP4P1ProteinHetionet hetionet:covaries:8818-90809Inferred only
DPM2 covaries with ZNF181ProteinHetionet hetionet:covaries:339318-8818Inferred only
DPM2 covaries with ZNF580ProteinHetionet hetionet:covaries:51157-8818Inferred only
DPM1 interacts with DPM2ProteinHetionet hetionet:interacts:8813-8818Inferred only
DPM2 interacts with DPM3ProteinHetionet hetionet:interacts:54344-8818Inferred only
PIGC interacts with DPM2ProteinHetionet hetionet:interacts:5279-8818Inferred only
DPM2 interacts with PIGPProteinHetionet hetionet:interacts:51227-8818Inferred only
DPM2 interacts with VKORC1ProteinHetionet hetionet:interacts:79001-8818Inferred only
DPM2 participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
DPM2 participates in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinPathwayReactome R-HSA-446193Inferred only
DPM2 participates in Defective DPM1 causes DPM1-CDGPathwayReactome R-HSA-4717374Inferred only

Show the remaining 30

DPM2 participates in Defective DPM2 causes DPM2-CDGPathwayReactome R-HSA-4719377Inferred only
DPM2 participates in Defective DPM3 causes DPM3-CDGPathwayReactome R-HSA-4719360Inferred only
DPM2 participates in Dengue Virus Genome Translation and ReplicationPathwayReactome R-HSA-9918487Inferred only
DPM2 participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only
DPM2 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
DPM2 participates in Diseases associated with glycosylation precursor biosynthesisPathwayReactome R-HSA-5609975Inferred only
DPM2 participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
DPM2 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
DPM2 participates in Glycosylation and related congenital defectsPathwayWikiPathways WP4521Inferred only
DPM2 participates in Glycosylphosphatidyl inositol anchor pathwayPathwayWikiPathways WP5505Inferred only
DPM2 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
DPM2 participates in Maturation of DENV proteinsPathwayReactome R-HSA-9918432Inferred only
DPM2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
DPM2 participates in N glycan biosynthesisPathwayWikiPathways WP5153Inferred only
DPM2 participates in Post-translational modification: synthesis of GPI-anchored proteinsPathwayReactome R-HSA-163125Inferred only
DPM2 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
DPM2 participates in Synthesis of dolichyl-phosphate mannosePathwayReactome R-HSA-162699Inferred only
DPM2 participates in Synthesis of glycosylphosphatidylinositol (GPI)PathwayReactome R-HSA-162710Inferred only
DPM2 participates in Synthesis of substrates in N-glycan biosythesisPathwayReactome R-HSA-446219Inferred only
DPM2 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
CD58 increases the expression of DPM2ProteinHetionet hetionet:regulates:965-8818Inferred only
IKBKG decreases the expression of DPM2ProteinHetionet hetionet:regulates:8517-8818Inferred only
NOTCH1 increases the expression of DPM2ProteinHetionet hetionet:regulates:4851-8818Inferred only
NR3C1 increases the expression of DPM2ProteinHetionet hetionet:regulates:2908-8818Inferred only
PISD decreases the expression of DPM2ProteinHetionet hetionet:regulates:23761-8818Inferred only
PLAT increases the expression of DPM2ProteinHetionet hetionet:regulates:5327-8818Inferred only
PREB decreases the expression of DPM2ProteinHetionet hetionet:regulates:10113-8818Inferred only
RCCD1 decreases the expression of DPM2ProteinHetionet hetionet:regulates:91433-8818Inferred only
SCARB1 decreases the expression of DPM2ProteinHetionet hetionet:regulates:949-8818Inferred only
WFS1 decreases the expression of DPM2ProteinHetionet hetionet:regulates:7466-8818Inferred only

Reactions

2 reactions

MAM01733c+MAM01951cMAM01734c+GDP
Catalysed by DPM1 & DPM2 & DPM3 or ALG12
Reaction pageLeft to rightBalancedEC 2.4.1.83cytosol
Human-GEM MAR07271CC BY 4.0Reference data
MAM01734r+MAM01896rMAM01733r+MAM01897r+proton
Catalysed by DPM1 & DPM2 & DPM3

Other names

2 names

Resolves to: DPM2

Also called: Dolichol-phosphate mannose synthase subunit 2DPM synthase subunit 2

← Every protein Find it in the graph →

or

Reaction pageLeft to rightBalancedEC 2.4.1.259endoplasmic reticulum

Human-GEM MAR07275CC BY 4.0Reference data