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Proteins/UNIPROT:Q8NES3
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning (By similarity)..
Function from UniProtKB (Q8NES3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
32 statements
32 statements · 7 reference databases · Subject: LFNG · Sources: Bgee, gene ontology, Hetionet, Reactome, Rhea, UniProt, WikiPathways
2 reactions
3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein]+UDP-N-acetyl-alpha-D-glucosamine3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein]+UDP+hydron
Catalysed by MFNG or LFNG or RFNG
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:70511CC BY 4.0Reference data
3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein]+UDP-N-acetyl-alpha-D-glucosamine3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein]
1 name
Resolves to: LFNG
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:70531CC BY 4.0Reference data