Proteins/UNIPROT:O94885

SASH1

ProteinUNIPROT:O94885

Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis..

Function from UniProtKB (O94885), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

dyschromatosis universalis hereditaria 1 has a germline basis in SASH1DiseaseGenCC HGNC:19182|MONDO:0024524Inferred only
familial generalized lentiginosis has a germline basis in SASH1DiseaseGenCC HGNC:19182|MONDO:0007891Inferred only
pigmentation defects-palmoplantar keratoderma-skin carcinoma syndrome has a germline basis in SASH1DiseaseGenCC HGNC:19182|MONDO:0018657Inferred only

Statements

21 statements

21 statements · 2 reference databases · Subject: SASH1 · Sources: gene ontology, Hetionet

Order

SASH1 covaries with CA11ProteinHetionet hetionet:covaries:23328-770Inferred only
CHRAC1 covaries with SASH1ProteinHetionet hetionet:covaries:23328-54108Inferred only
SASH1 covaries with ETFBKMTProteinHetionet hetionet:covaries:23328-254013Inferred only
MANSC4 covaries with SASH1ProteinHetionet hetionet:covaries:100287284-23328Inferred only
SASH1 covaries with PCAREProteinHetionet hetionet:covaries:23328-388939Inferred only
SASH1 covaries with RFNGProteinHetionet hetionet:covaries:23328-5986Inferred only
SASH1 covaries with TMEM238ProteinHetionet hetionet:covaries:23328-388564Inferred only
KHDRBS1 interacts with SASH1ProteinHetionet hetionet:interacts:10657-23328Inferred only
SASH1 interacts with MED28ProteinHetionet hetionet:interacts:23328-80306Inferred only
NCK1 interacts with SASH1ProteinHetionet hetionet:interacts:23328-4690Inferred only
SKIL interacts with SASH1ProteinHetionet hetionet:interacts:23328-6498Inferred only
UBC interacts with SASH1ProteinHetionet hetionet:interacts:23328-7316Inferred only

Show the remaining 9

SASH1 regulates positive regulation of angiogenesisBiological processgene ontology O94885|GO:0045766Inferred only
SASH1 regulates positive regulation of endothelial cell migrationBiological processgene ontology O94885|GO:0010595Inferred only
SASH1 regulates positive regulation of JUN kinase activityBiological processgene ontology O94885|GO:0043507Inferred only
SASH1 regulates positive regulation of lipopolysaccharide-mediated signaling pathwayBiological processgene ontology O94885|GO:0031666Inferred only
SASH1 regulates positive regulation of non-canonical NF-kappaB signal transductionBiological processgene ontology O94885|GO:1901224Inferred only
SASH1 regulates positive regulation of p38MAPK cascadeBiological processgene ontology O94885|GO:1900745Inferred only
SASH1 regulates regulation of epithelial cell migrationBiological processgene ontology O94885|GO:0010632Inferred only
SASH1 regulates regulation of protein autoubiquitinationBiological processgene ontology O94885|GO:1902498Inferred only
SASH1 regulates regulation of protein K63-linked ubiquitinationBiological processgene ontology O94885|GO:1900044Inferred only

Other names

4 names

Resolves to: SASH1

Also called: KIAA0790PEPE1Proline-glutamate repeat-containing proteinSAM and SH3 domain-containing protein 1

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