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Proteins/UNIPROT:O14807
Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation. The formation of the SMP complex only occurs when MRAS is GTP-bound. Unlike other Ras proteins, MRAS has low intrinsic GTPase activity and may require additional factors for activation. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex..
Function from UniProtKB (O14807), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
46 statements
46 statements · 5 reference databases · Subject: MRAS · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
1 reaction
2 names
Resolves to: MRAS
Rhea RHEA:19669CC BY 4.0Reference data