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Proteins/UNIPROT:Q70JA7
Catalytic component of CHSY1-CHPF2 and CHSY1-CHPF chondroitin sulfate synthase complexes. Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1..
Function from UniProtKB (Q70JA7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
33 statements
33 statements · 6 reference databases · Subject: CHSY3 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
12 reactions
MAM01563g+UDP-alpha-D-glucuronateMAM01564g+proton+UDP
Catalysed by CHPF2 or CHPF or CHSY1 or CHSY3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.175, 2.4.1.226Golgi apparatus
Human-GEM MAR07493CC BY 4.0Reference data
MAM01564g+CHEBI:16264MAM01565g+proton+UDP
9 names
Resolves to: CHSY3
Catalysed by CHPF or CHSY1 or CSGALNACT1 or CSGALNACT2 or CHSY3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.226Golgi apparatus
Human-GEM MAR07494CC BY 4.0Reference data
MAM01518g+UDP-alpha-D-glucuronateMAM01515g+proton+UDP
Catalysed by CHPF2 or CHPF or CHSY1 or CHSY3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.175, 2.4.1.226Golgi apparatus
Human-GEM MAR07495CC BY 4.0Reference data
MAM01515g+CHEBI:16264MAM01516g+proton+UDP
Catalysed by CHPF or CHSY1 or CSGALNACT1 or CSGALNACT2 or CHSY3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.226Golgi apparatus
Human-GEM MAR07496CC BY 4.0Reference data
MAM01532g+UDP-alpha-D-glucuronateMAM01540g+proton+UDP
Catalysed by CHPF2 or CHPF or CHSY1 or CHSY3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.175, 2.4.1.226Golgi apparatus
Human-GEM MAR07520CC BY 4.0Reference data
MAM01540g+CHEBI:16264MAM01541g+proton+UDP
Catalysed by CHPF or CHSY1 or CSGALNACT1 or CSGALNACT2 or CHSY3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.226Golgi apparatus
Human-GEM MAR07521CC BY 4.0Reference data
MAM01542g+UDP-alpha-D-glucuronateMAM01551g+proton+UDP
Catalysed by CHPF2 or CHPF or CHSY1 or CHSY3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.175, 2.4.1.226Golgi apparatus
Human-GEM MAR07535CC BY 4.0Reference data
MAM01551g+CHEBI:16264MAM01552g+proton+UDP
Catalysed by CHPF or CHSY1 or CSGALNACT1 or CSGALNACT2 or CHSY3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.226Golgi apparatus
Human-GEM MAR07536CC BY 4.0Reference data
3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]+UDP-N-acetyl-alpha-D-galactosamine3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]+UDP+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:20800CC BY 4.0Reference data
3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]+UDP-alpha-D-glucuronate3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]+UDP+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:23428CC BY 4.0Reference data
3-O-{[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein]+UDP-alpha-D-glucuronate3-O-{beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein]+UDP+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54996CC BY 4.0Reference data
3-O-{beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein]+UDP-N-acetyl-alpha-D-galactosamine3-O-{[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein]+UDP+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:55000CC BY 4.0Reference data