Proteins/UNIPROT:P11686

SFTPC

ProteinUNIPROT:P11686

Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.

Function from UniProtKB (P11686), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

chronic respiratory distress with surfactant metabolism deficiency has a germline basis in SFTPCDiseaseGenCC HGNC:10802|MONDO:0016323Inferred only
SFTPC-related interstitial lung disease has a germline basis in SFTPCDiseaseGenCC HGNC:10802|MONDO:0018603Inferred only
surfactant metabolism dysfunction, pulmonary, 2 has a germline basis in SFTPCDiseaseGenCC HGNC:10802|MONDO:0024465Inferred only

Statements

28 statements

28 statements · 3 reference databases · Subject: SFTPC · Sources: Hetionet, Reactome, WikiPathways

Order

SFTPC covaries with CTBP1ProteinHetionet hetionet:covaries:1487-6440Inferred only
SFTPC covaries with DCHS2ProteinHetionet hetionet:covaries:54798-6440Inferred only
NEDD4 interacts with SFTPCProteinHetionet hetionet:interacts:4734-6440Inferred only
SFTPC interacts with TMEM67ProteinHetionet hetionet:interacts:6440-91147Inferred only
SFTPC interacts with VCPProteinHetionet hetionet:interacts:6440-7415Inferred only
SFTPC interacts with WWP1ProteinHetionet hetionet:interacts:11059-6440Inferred only
SFTPC interacts with WWP2ProteinHetionet hetionet:interacts:11060-6440Inferred only
SFTPC participates in Circadian rhythm genesPathwayWikiPathways WP3594Inferred only
SFTPC participates in Defective CSF2RA causes SMDP4PathwayReactome R-HSA-5688890Inferred only
SFTPC participates in Defective CSF2RB causes SMDP5PathwayReactome R-HSA-5688849Inferred only
SFTPC participates in Defective pro-SFTPC causes SMDP2 and RDSPathwayReactome R-HSA-5688354Inferred only
SFTPC participates in DiseasePathwayReactome R-HSA-1643685Inferred only

Show the remaining 16

SFTPC participates in Diseases associated with surfactant metabolismPathwayReactome R-HSA-5687613Inferred only
SFTPC participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
SFTPC participates in Lung fibrosisPathwayWikiPathways WP3624Inferred only
SFTPC participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
SFTPC participates in Surfactant metabolismPathwayReactome R-HSA-5683826Inferred only
AGL increases the expression of SFTPCProteinHetionet hetionet:regulates:178-6440Inferred only
GRB2 increases the expression of SFTPCProteinHetionet hetionet:regulates:2885-6440Inferred only
HSF1 increases the expression of SFTPCProteinHetionet hetionet:regulates:3297-6440Inferred only
IGF1R increases the expression of SFTPCProteinHetionet hetionet:regulates:3480-6440Inferred only
ITGB1BP1 increases the expression of SFTPCProteinHetionet hetionet:regulates:9270-6440Inferred only
JMJD6 increases the expression of SFTPCProteinHetionet hetionet:regulates:23210-6440Inferred only
KTN1 increases the expression of SFTPCProteinHetionet hetionet:regulates:3895-6440Inferred only
MOK decreases the expression of SFTPCProteinHetionet hetionet:regulates:5891-6440Inferred only
NQO1 increases the expression of SFTPCProteinHetionet hetionet:regulates:1728-6440Inferred only
POLG2 decreases the expression of SFTPCProteinHetionet hetionet:regulates:11232-6440Inferred only
PTMS increases the expression of SFTPCProteinHetionet hetionet:regulates:5763-6440Inferred only

Other names

5 names

Resolves to: SFTPC

Also called: Pulmonary surfactant-associated protein CPulmonary surfactant-associated proteolipid SPL(Val)SFTP2SP-CSP5

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