Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q9NQV8

PRDM8

Protein·UNIPROT:Q9NQV8

Open in the graph

Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity)..

Function from UniProtKB (Q9NQV8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

early-onset Lafora body disease has a germline basis in PRDM8DiseaseGenCC HGNC:13993|MONDO:0014717Inferred only

Statements

12 statements

12 statements · 3 reference databases · Subject: PRDM8 · Sources: gene ontology, Hetionet, Reactome

Search this listOrder

PRDM8 covaries with LPIN3ProteinHetionet hetionet:covaries:56978-64900Inferred only
PLAAT3 covaries with PRDM8ProteinHetionet hetionet:covaries:11145-56978Inferred only
PRDM8 interacts with NHLRC1ProteinHetionet hetionet:interacts:378884-56978Inferred only
PRDM8 participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only
PRDM8 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
PRDM8 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
PRDM8 participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only
PRDM8 participates in Regulation of CDH11 Expression and FunctionPathwayReactome R-HSA-9759475Inferred only
PRDM8 participates in Regulation of CDH11 gene transcriptionPathwayReactome R-HSA-9762293Inferred only
PRDM8 participates in Regulation of Expression and Function of Type II Classical CadherinsPathwayReactome R-HSA-9764260Inferred only
PRDM8 participates in Regulation of Homotypic Cell-Cell AdhesionPathwayReactome R-HSA-9759476Inferred only
PRDM8 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q9NQV8|GO:0006355Inferred only

Other names

2 names

Resolves to: PRDM8

Also called: PFM5PR domain-containing protein 8

← Every protein Find it in the graph →