Proteins/UNIPROT:Q9H244

P2RY12

ProteinUNIPROT:Q9H244

Receptor for ADP and ATP coupled to G proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation..

Function from UniProtKB (Q9H244), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

P2RY12-related platelet disorder, autosomal dominant has a germline basis in P2RY12DiseaseGenCC HGNC:18124|MONDO:1060234Inferred only
platelet-type bleeding disorder 8 has a germline basis in P2RY12DiseaseGenCC HGNC:18124|MONDO:0012354Inferred only

Statements

57 statements

57 statements · 4 reference databases · Subject: P2RY12 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

GNAI2 interacts with P2RY12ProteinHetionet hetionet:interacts:2771-64805Inferred only
P2RY12 participates in ADP signalling through P2Y purinoceptor 12PathwayReactome R-HSA-392170Inferred only
P2RY12 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
P2RY12 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
P2RY12 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
P2RY12 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
P2RY12 participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
P2RY12 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
P2RY12 participates in Integrative Analysis of Treg Glial Interactions PathwayWikiPathways WP5561Inferred only
P2RY12 participates in Nucleotide-like (purinergic) receptorsPathwayReactome R-HSA-418038Inferred only
P2RY12 participates in P2Y receptorsPathwayReactome R-HSA-417957Inferred only
P2RY12 participates in Platelet activation, signaling and aggregationPathwayReactome R-HSA-76002Inferred only

Show the remaining 45

P2RY12 participates in Purinergic signalingPathwayWikiPathways WP4900Inferred only
P2RY12 participates in Signal amplificationPathwayReactome R-HSA-392518Inferred only
P2RY12 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
P2RY12 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
P2RY12 regulates positive regulation of cell adhesion mediated by integrinBiological processgene ontology Q9H244|GO:0033630Inferred only
P2RY12 regulates positive regulation of chemotaxisBiological processgene ontology Q9H244|GO:0050921Inferred only
P2RY12 regulates positive regulation of integrin activation by cell surface receptor linked signal transductionBiological processgene ontology Q9H244|GO:0033626Inferred only
P2RY12 regulates positive regulation of microglial cell migrationBiological processgene ontology Q9H244|GO:1904141Inferred only
P2RY12 regulates positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionBiological processgene ontology Q9H244|GO:0051897Inferred only
P2RY12 regulates positive regulation of ruffle assemblyBiological processgene ontology Q9H244|GO:1900029Inferred only
P2RY12 regulates regulation of chemotaxisBiological processgene ontology Q9H244|GO:0050920Inferred only
P2RY12 regulates regulation of microglial cell migrationBiological processgene ontology Q9H244|GO:1904139Inferred only
P2RY12 decreases the expression of AMIGO2ProteinHetionet hetionet:regulates:64805-347902Inferred only
P2RY12 decreases the expression of ANXA1ProteinHetionet hetionet:regulates:64805-301Inferred only
P2RY12 decreases the expression of ARNT2ProteinHetionet hetionet:regulates:64805-9915Inferred only
P2RY12 increases the expression of CCNA2ProteinHetionet hetionet:regulates:64805-890Inferred only
P2RY12 decreases the expression of CDC20ProteinHetionet hetionet:regulates:64805-991Inferred only
P2RY12 increases the expression of CHEK2ProteinHetionet hetionet:regulates:64805-11200Inferred only
P2RY12 decreases the expression of COTL1ProteinHetionet hetionet:regulates:64805-23406Inferred only
P2RY12 decreases the expression of CSNK2A2ProteinHetionet hetionet:regulates:64805-1459Inferred only
P2RY12 decreases the expression of DNM1LProteinHetionet hetionet:regulates:64805-10059Inferred only
P2RY12 decreases the expression of EPAS1ProteinHetionet hetionet:regulates:64805-2034Inferred only
P2RY12 increases the expression of EZH2ProteinHetionet hetionet:regulates:64805-2146Inferred only
P2RY12 decreases the expression of HMG20BProteinHetionet hetionet:regulates:64805-10362Inferred only
P2RY12 decreases the expression of LGALS1ProteinHetionet hetionet:regulates:64805-3956Inferred only
P2RY12 increases the expression of LPLProteinHetionet hetionet:regulates:64805-4023Inferred only
P2RY12 increases the expression of MCUR1ProteinHetionet hetionet:regulates:64805-63933Inferred only
P2RY12 decreases the expression of MESTProteinHetionet hetionet:regulates:64805-4232Inferred only
P2RY12 decreases the expression of MSNProteinHetionet hetionet:regulates:64805-4478Inferred only
P2RY12 decreases the expression of NPTX2ProteinHetionet hetionet:regulates:64805-4885Inferred only
P2RY12 decreases the expression of NT5EProteinHetionet hetionet:regulates:64805-4907Inferred only
P2RY12 decreases the expression of OSBPL10ProteinHetionet hetionet:regulates:64805-114884Inferred only
P2RY12 decreases the expression of PEG10ProteinHetionet hetionet:regulates:64805-23089Inferred only
P2RY12 increases the expression of PLAC8ProteinHetionet hetionet:regulates:64805-51316Inferred only
P2RY12 increases the expression of PLCB3ProteinHetionet hetionet:regulates:64805-5331Inferred only
P2RY12 increases the expression of POLE2ProteinHetionet hetionet:regulates:64805-5427Inferred only
P2RY12 decreases the expression of PRKACAProteinHetionet hetionet:regulates:64805-5566Inferred only
P2RY12 decreases the expression of RAI14ProteinHetionet hetionet:regulates:64805-26064Inferred only
P2RY12 increases the expression of SELLProteinHetionet hetionet:regulates:64805-6402Inferred only
P2RY12 decreases the expression of SPRED2ProteinHetionet hetionet:regulates:64805-200734Inferred only
P2RY12 decreases the expression of TRIB3ProteinHetionet hetionet:regulates:64805-57761Inferred only
P2RY12 decreases the expression of UBE2SProteinHetionet hetionet:regulates:64805-27338Inferred only
P2RY12 decreases the expression of UTRNProteinHetionet hetionet:regulates:64805-7402Inferred only
P2RY12 decreases the expression of VPS28ProteinHetionet hetionet:regulates:64805-51160Inferred only
P2RY12 decreases the expression of ZNF395ProteinHetionet hetionet:regulates:64805-55893Inferred only

Other names

10 names

Resolves to: P2RY12

Also called: ADP-glucose receptorADPG-RHORK3P2T(AC)P2Y(AC)P2Y(ADP)P2Y(cyc)P2Y12P2Y12 platelet ADP receptorSP1999

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