Loading the page.
Proteins/UNIPROT:Q96QT4
Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx. Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7. In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions..
[TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling..
[TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development..
Function from UniProtKB (Q96QT4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 3 · transported by
3 compounds
3 compounds.
0 reported routes3 assembled routes
5 rows
27 statements
27 statements · 7 reference databases · Subject: TRPM7 · Sources: Bgee, Hetionet, Human Protein Atlas, Reactome, Rhea, UniProt, WikiPathways
5 reactions
7 names
Resolves to: TRPM7
Rhea RHEA:17989CC BY 4.0Reference data
Transported by TRPA1 or SLC39A6 or SLC39A12 or SLC39A4 or SLC30A10 or SLC39A5 or SLC39A11 or SLC30A7 or TMEM163 or SLC39A7 or SLC39A13 or TRPM7 and 7 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:29351CC BY 4.0Reference data
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data
Transported by TMEM150C or TRPA1 or VDAC1 or GRIA1 or HTR3A or GRIA4 or CLDN10 or NIPAL4 or TMEM63B or NIPAL1 or NIPA1 or PKD1L3 and 17 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:29827CC BY 4.0Reference data