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Proteins/UNIPROT:Q9H598
Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity)..
Function from UniProtKB (Q9H598), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
2 rows
44 statements
44 statements · 6 reference databases · Subject: SLC32A1 · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
9 reactions
ATP+beta-alanine+waterADP+beta-alanine+proton+phosphate(3-)
Transported by SLC32A1
Reaction pageLeft to rightBalancedEC 2.3.1.65cytosol, extracellular space
Human-GEM MAR00087CC BY 4.0Reference data
6 names
Resolves to: SLC32A1
Transported by SLC32A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01314CC BY 4.0Reference data
ATP+glycine+waterADP+glycine+proton+phosphate(3-)
Transported by SLC32A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01396CC BY 4.0Reference data
ATP+3beta-alanine+waterADP+3beta-alanine+proton+phosphate(3-)
Transported by SLC32A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07736CC BY 4.0Reference data
ATP+3glycine+waterADP+3glycine+proton+phosphate(3-)
Transported by SLC32A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07737CC BY 4.0Reference data
34-aminobutanoate+ATP+water34-aminobutanoate+ADP+proton+phosphate(3-)
Transported by SLC32A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07738CC BY 4.0Reference data
4-aminobutanoate+nhydron4-aminobutanoate+nhydron
Transported by SLC32A1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:70979CC BY 4.0Reference data
glycine+nhydronglycine+nhydron
Transported by SLC32A1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:70983CC BY 4.0Reference data
beta-alanine+nhydronbeta-alanine+nhydron
Transported by SLC32A1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:70987CC BY 4.0Reference data