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Proteins/UNIPROT:Q99608
Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences (By similarity)..
Function from UniProtKB (Q99608), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
457 statements
457 statements · 4 reference databases · Subject: NDN · Sources: gene ontology, Hetionet, Reactome, WikiPathways · Rows fetched: 300
1 name
Resolves to: NDN