Proteins/UNIPROT:P17600

SYN1

ProteinUNIPROT:P17600

Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal. Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity)..

Function from UniProtKB (P17600), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

epilepsy, X-linked 1, with variable learning disabilities and behavior disorders has a germline basis in SYN1DiseaseGenCC HGNC:11494|MONDO:0010339Inferred only
intellectual disability, X-linked 50 has a germline basis in SYN1DiseaseGenCC HGNC:11494|MONDO:0010251Inferred only
X-linked complex neurodevelopmental disorder has a germline basis in SYN1DiseaseGenCC HGNC:11494|MONDO:0100148Inferred only

Statements

153 statements

153 statements · 4 reference databases · Subject: SYN1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

SYN1 covaries with AAMPProteinHetionet hetionet:covaries:14-6853Inferred only
SYN1 covaries with AAR2ProteinHetionet hetionet:covaries:25980-6853Inferred only
SYN1 covaries with ADAMTS10ProteinHetionet hetionet:covaries:6853-81794Inferred only
SYN1 covaries with ADGRB2ProteinHetionet hetionet:covaries:576-6853Inferred only
SYN1 covaries with ANAPC2ProteinHetionet hetionet:covaries:29882-6853Inferred only
ARAF covaries with SYN1ProteinHetionet hetionet:covaries:369-6853Inferred only
SYN1 covaries with B4GAT1ProteinHetionet hetionet:covaries:11041-6853Inferred only
BCORL1 covaries with SYN1ProteinHetionet hetionet:covaries:63035-6853Inferred only
BTBD19 covaries with SYN1ProteinHetionet hetionet:covaries:149478-6853Inferred only
SYN1 covaries with C1orf122ProteinHetionet hetionet:covaries:127687-6853Inferred only
CAPN6 covaries with SYN1ProteinHetionet hetionet:covaries:6853-827Inferred only
SYN1 covaries with CBLN2ProteinHetionet hetionet:covaries:147381-6853Inferred only

Show the remaining 141

CCDC22 covaries with SYN1ProteinHetionet hetionet:covaries:28952-6853Inferred only
SYN1 covaries with CRXProteinHetionet hetionet:covaries:1406-6853Inferred only
SYN1 covaries with DDX50ProteinHetionet hetionet:covaries:6853-79009Inferred only
SYN1 covaries with DHX40ProteinHetionet hetionet:covaries:6853-79665Inferred only
DIO3 covaries with SYN1ProteinHetionet hetionet:covaries:1735-6853Inferred only
SYN1 covaries with DTX3ProteinHetionet hetionet:covaries:196403-6853Inferred only
ELK1 covaries with SYN1ProteinHetionet hetionet:covaries:2002-6853Inferred only
ENOX2 covaries with SYN1ProteinHetionet hetionet:covaries:10495-6853Inferred only
SYN1 covaries with EPM2AIP1ProteinHetionet hetionet:covaries:6853-9852Inferred only
SYN1 covaries with ERI3ProteinHetionet hetionet:covaries:6853-79033Inferred only
FGD1 covaries with SYN1ProteinHetionet hetionet:covaries:2245-6853Inferred only
SYN1 covaries with GAL3ST3ProteinHetionet hetionet:covaries:6853-89792Inferred only
SYN1 covaries with GALR3ProteinHetionet hetionet:covaries:6853-8484Inferred only
GPC3 covaries with SYN1ProteinHetionet hetionet:covaries:2719-6853Inferred only
SYN1 covaries with GPR6ProteinHetionet hetionet:covaries:2830-6853Inferred only
GRIPAP1 covaries with SYN1ProteinHetionet hetionet:covaries:56850-6853Inferred only
SYN1 covaries with H2BC4; H2BC6; H2BC7; H2BC8; H2BC10ProteinHetionet hetionet:covaries:6853-8339Inferred only
SYN1 covaries with HES7ProteinHetionet hetionet:covaries:6853-84667Inferred only
HNRNPH2 covaries with SYN1ProteinHetionet hetionet:covaries:3188-6853Inferred only
SYN1 covaries with HOXC13ProteinHetionet hetionet:covaries:3229-6853Inferred only
HTR2C covaries with SYN1ProteinHetionet hetionet:covaries:3358-6853Inferred only
SYN1 covaries with IGIPProteinHetionet hetionet:covaries:492311-6853Inferred only
IRS4 covaries with SYN1ProteinHetionet hetionet:covaries:6853-8471Inferred only
ITGB1BP2 covaries with SYN1ProteinHetionet hetionet:covaries:26548-6853Inferred only
KDM5C covaries with SYN1ProteinHetionet hetionet:covaries:6853-8242Inferred only
SYN1 covaries with KLHL35ProteinHetionet hetionet:covaries:283212-6853Inferred only
LOXHD1 covaries with SYN1ProteinHetionet hetionet:covaries:125336-6853Inferred only
SYN1 covaries with LRRC14ProteinHetionet hetionet:covaries:6853-9684Inferred only
SYN1 covaries with LRRC41ProteinHetionet hetionet:covaries:10489-6853Inferred only
SYN1 covaries with LYPLA2ProteinHetionet hetionet:covaries:11313-6853Inferred only
SYN1 covaries with LZTS3ProteinHetionet hetionet:covaries:6853-9762Inferred only
SYN1 covaries with MBTPS2ProteinHetionet hetionet:covaries:51360-6853Inferred only
SYN1 covaries with MICOS13ProteinHetionet hetionet:covaries:125988-6853Inferred only
SYN1 covaries with MSL2ProteinHetionet hetionet:covaries:55167-6853Inferred only
NALF2 covaries with SYN1ProteinHetionet hetionet:covaries:27112-6853Inferred only
SYN1 covaries with NAT14ProteinHetionet hetionet:covaries:57106-6853Inferred only
SYN1 covaries with NDNProteinHetionet hetionet:covaries:4692-6853Inferred only
NKRF covaries with SYN1ProteinHetionet hetionet:covaries:55922-6853Inferred only
SYN1 covaries with NKX2-1ProteinHetionet hetionet:covaries:6853-7080Inferred only
SYN1 covaries with NKX2-5ProteinHetionet hetionet:covaries:1482-6853Inferred only
SYN1 covaries with NRN1ProteinHetionet hetionet:covaries:51299-6853Inferred only
SYN1 covaries with NSMCE2ProteinHetionet hetionet:covaries:286053-6853Inferred only
PCDH19 covaries with SYN1ProteinHetionet hetionet:covaries:57526-6853Inferred only
SYN1 covaries with PGAP4ProteinHetionet hetionet:covaries:6853-84302Inferred only
SYN1 covaries with PHF12ProteinHetionet hetionet:covaries:57649-6853Inferred only
SYN1 covaries with PHF20ProteinHetionet hetionet:covaries:51230-6853Inferred only
SYN1 covaries with PKIAProteinHetionet hetionet:covaries:5569-6853Inferred only
SYN1 covaries with PLEKHB1ProteinHetionet hetionet:covaries:58473-6853Inferred only
SYN1 covaries with PNKDProteinHetionet hetionet:covaries:25953-6853Inferred only
SYN1 covaries with POLR2MProteinHetionet hetionet:covaries:6853-81488Inferred only
SYN1 covaries with PPFIA3ProteinHetionet hetionet:covaries:6853-8541Inferred only
PPP1R3F covaries with SYN1ProteinHetionet hetionet:covaries:6853-89801Inferred only
SYN1 covaries with PREPLProteinHetionet hetionet:covaries:6853-9581Inferred only
SYN1 covaries with PRKRAProteinHetionet hetionet:covaries:6853-8575Inferred only
SYN1 covaries with PTPRFProteinHetionet hetionet:covaries:5792-6853Inferred only
SYN1 covaries with RBM14ProteinHetionet hetionet:covaries:10432-6853Inferred only
SYN1 covaries with RIMOC1ProteinHetionet hetionet:covaries:285636-6853Inferred only
RNF112 covaries with SYN1ProteinHetionet hetionet:covaries:6853-7732Inferred only
RNF128 covaries with SYN1ProteinHetionet hetionet:covaries:6853-79589Inferred only
SYN1 covaries with RNF214ProteinHetionet hetionet:covaries:257160-6853Inferred only
SYN1 covaries with RNF215ProteinHetionet hetionet:covaries:200312-6853Inferred only
SYN1 covaries with RTN4RProteinHetionet hetionet:covaries:65078-6853Inferred only
SERF2 covaries with SYN1ProteinHetionet hetionet:covaries:10169-6853Inferred only
SYN1 covaries with SHFLProteinHetionet hetionet:covaries:55337-6853Inferred only
SYN1 covaries with SLC4A3ProteinHetionet hetionet:covaries:6508-6853Inferred only
SYN1 covaries with SMC5ProteinHetionet hetionet:covaries:23137-6853Inferred only
SYN1 covaries with SNTA1ProteinHetionet hetionet:covaries:6640-6853Inferred only
SYN1 covaries with SP7ProteinHetionet hetionet:covaries:121340-6853Inferred only
SYN1 covaries with SPRED3ProteinHetionet hetionet:covaries:399473-6853Inferred only
SPRY3 covaries with SYN1ProteinHetionet hetionet:covaries:10251-6853Inferred only
SYN1 covaries with ST6GALNAC4ProteinHetionet hetionet:covaries:27090-6853Inferred only
SYN1 covaries with STAU2ProteinHetionet hetionet:covaries:27067-6853Inferred only
SYN1 covaries with SZT2ProteinHetionet hetionet:covaries:23334-6853Inferred only
SYN1 covaries with TEAD2ProteinHetionet hetionet:covaries:6853-8463Inferred only
TFE3 covaries with SYN1ProteinHetionet hetionet:covaries:6853-7030Inferred only
SYN1 covaries with THAP11ProteinHetionet hetionet:covaries:57215-6853Inferred only
SYN1 covaries with THAP12ProteinHetionet hetionet:covaries:5612-6853Inferred only
TMEM35A covaries with SYN1ProteinHetionet hetionet:covaries:59353-6853Inferred only
SYN1 covaries with TMEM63BProteinHetionet hetionet:covaries:55362-6853Inferred only
TNMD covaries with SYN1ProteinHetionet hetionet:covaries:64102-6853Inferred only
TPBGL covaries with SYN1ProteinHetionet hetionet:covaries:100507050-6853Inferred only
SYN1 covaries with TRAF4ProteinHetionet hetionet:covaries:6853-9618Inferred only
TRIM66 covaries with SYN1ProteinHetionet hetionet:covaries:6853-9866Inferred only
SYN1 covaries with TRIM68ProteinHetionet hetionet:covaries:55128-6853Inferred only
SYN1 covaries with TRIML1ProteinHetionet hetionet:covaries:339976-6853Inferred only
TRPC5 covaries with SYN1ProteinHetionet hetionet:covaries:6853-7224Inferred only
SYN1 covaries with TUBProteinHetionet hetionet:covaries:6853-7275Inferred only
SYN1 covaries with VEGFBProteinHetionet hetionet:covaries:6853-7423Inferred only
SYN1 covaries with WNT1ProteinHetionet hetionet:covaries:6853-7471Inferred only
SYN1 covaries with ZNF10ProteinHetionet hetionet:covaries:6853-7556Inferred only
SYN1 covaries with ZNF197ProteinHetionet hetionet:covaries:10168-6853Inferred only
SYN1 covaries with ZNF24ProteinHetionet hetionet:covaries:6853-7572Inferred only
SYN1 covaries with ZNF26ProteinHetionet hetionet:covaries:6853-7574Inferred only
ZNF286A covaries with SYN1ProteinHetionet hetionet:covaries:57335-6853Inferred only
SYN1 covaries with ZNF502ProteinHetionet hetionet:covaries:6853-91392Inferred only
SYN1 covaries with ZNF660ProteinHetionet hetionet:covaries:285349-6853Inferred only
ZNF711 covaries with SYN1ProteinHetionet hetionet:covaries:6853-7552Inferred only
SYN1 covaries with ZNF879ProteinHetionet hetionet:covaries:345462-6853Inferred only
AMPH interacts with SYN1ProteinHetionet hetionet:interacts:273-6853Inferred only
BIN1 interacts with SYN1ProteinHetionet hetionet:interacts:274-6853Inferred only
BLM interacts with SYN1ProteinHetionet hetionet:interacts:641-6853Inferred only
SYN1 interacts with CAMK1ProteinHetionet hetionet:interacts:6853-8536Inferred only
CAMK2G interacts with SYN1ProteinHetionet hetionet:interacts:6853-818Inferred only
CDK5 interacts with SYN1ProteinHetionet hetionet:interacts:1020-6853Inferred only
CRK interacts with SYN1ProteinHetionet hetionet:interacts:1398-6853Inferred only
EGFR interacts with SYN1ProteinHetionet hetionet:interacts:1956-6853Inferred only
GRB2 interacts with SYN1ProteinHetionet hetionet:interacts:2885-6853Inferred only
SYN1 interacts with KAT5ProteinHetionet hetionet:interacts:10524-6853Inferred only
MAPK3 interacts with SYN1ProteinHetionet hetionet:interacts:5595-6853Inferred only
SYN1 interacts with NCF1ProteinHetionet hetionet:interacts:653361-6853Inferred only
NOS1 interacts with SYN1ProteinHetionet hetionet:interacts:4842-6853Inferred only
SYN1 interacts with NOS1APProteinHetionet hetionet:interacts:6853-9722Inferred only
PAK1 interacts with SYN1ProteinHetionet hetionet:interacts:5058-6853Inferred only
PAK2 interacts with SYN1ProteinHetionet hetionet:interacts:5062-6853Inferred only
PAK3 interacts with SYN1ProteinHetionet hetionet:interacts:5063-6853Inferred only
PFN2 interacts with SYN1ProteinHetionet hetionet:interacts:5217-6853Inferred only
PIK3R1 interacts with SYN1ProteinHetionet hetionet:interacts:5295-6853Inferred only
PLCG1 interacts with SYN1ProteinHetionet hetionet:interacts:5335-6853Inferred only
PRKACA interacts with SYN1ProteinHetionet hetionet:interacts:5566-6853Inferred only
RASA1 interacts with SYN1ProteinHetionet hetionet:interacts:5921-6853Inferred only
S100A1 interacts with SYN1ProteinHetionet hetionet:interacts:6271-6853Inferred only
SH3GL2 interacts with SYN1ProteinHetionet hetionet:interacts:6456-6853Inferred only
SNCA interacts with SYN1ProteinHetionet hetionet:interacts:6622-6853Inferred only
SRC interacts with SYN1ProteinHetionet hetionet:interacts:6714-6853Inferred only
SYN1 interacts with SYN2ProteinHetionet hetionet:interacts:6853-6854Inferred only
SYN1 interacts with VIMProteinHetionet hetionet:interacts:6853-7431Inferred only
SYN1 participates in Brain derived neurotrophic factor BDNF signalingPathwayWikiPathways WP2380Inferred only
SYN1 participates in Dopamine Neurotransmitter Release CyclePathwayReactome R-HSA-212676Inferred only
SYN1 participates in Monoamine transport and regulationPathwayWikiPathways WP727Inferred only
SYN1 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
SYN1 participates in Neurotransmitter release cyclePathwayReactome R-HSA-112310Inferred only
SYN1 participates in NF1 copy number variation syndrome PathwayWikiPathways WP5366Inferred only
SYN1 participates in Sensory PerceptionPathwayReactome R-HSA-9709957Inferred only
SYN1 participates in Sensory processing of soundPathwayReactome R-HSA-9659379Inferred only
SYN1 participates in Sensory processing of sound by inner hair cells of the cochleaPathwayReactome R-HSA-9662360Inferred only
SYN1 participates in Serotonin Neurotransmitter Release CyclePathwayReactome R-HSA-181429Inferred only
SYN1 participates in Synaptic vesicle pathwayPathwayWikiPathways WP2267Inferred only
SYN1 participates in Transmission across Chemical SynapsesPathwayReactome R-HSA-112315Inferred only
SYN1 regulates regulation of neurotransmitter secretionBiological processgene ontology P17600|GO:0046928Inferred only
SYN1 regulates regulation of synaptic vesicle cycleBiological processgene ontology P17600|GO:0098693Inferred only
SYN1 regulates regulation of synaptic vesicle exocytosisBiological processgene ontology P17600|GO:2000300Inferred only

Other names

2 names

Resolves to: SYN1

Also called: Brain protein 4.1Synapsin I

← Every protein Find it in the graph →