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Proteins/UNIPROT:Q9NQX7
Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity)..
Function from UniProtKB (Q9NQX7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
58 statements
58 statements · 2 reference databases · Subject: ITM2C · Sources: gene ontology, Hetionet
4 names
Resolves to: ITM2C