RAD54L2

Helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner (By similarity). May stimulate the release of RNA polymerase II, that has paused near the transcription start sites of AR-targeted genes and unwind R-loops formed at these sites; R-loops result from the hybridization of the short RNA strand nascently synthesized by the paused RNA polymerase II molecule and the DNA template. May also stimulate double-strand break formation by TOP2B, which appears important for transcriptional output. Not able to remodel mononucleosomes in vitro (By similarity)..

Function from UniProtKB (Q9Y4B4), read 2026-09-23. CC BY 4.0.