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Proteins/UNIPROT:P16112

ACAN

Protein·UNIPROT:P16112

Open in the graph

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

Function from UniProtKB (P16112), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

6 rows

ACAN-related short stature spectrum has a germline basis in ACANDiseaseGenCC HGNC:319|MONDO:1060149Inferred only
osteochondritis dissecans has a germline basis in ACANDiseaseGenCC HGNC:319|MONDO:0017178Inferred only
short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans has a germline basis in ACANDiseaseGenCC HGNC:319|MONDO:0100462Inferred only
short stature-advanced bone age-early-onset osteoarthritis syndrome has a germline basis in ACANDiseaseGenCC HGNC:319|MONDO:0018566Inferred only
spondyloepimetaphyseal dysplasia, aggrecan type has a germline basis in ACANDiseaseGenCC HGNC:319|MONDO:0013014Inferred only
spondyloepiphyseal dysplasia, Kimberley type has a germline basis in ACANDiseaseGenCC HGNC:319|MONDO:0012019Inferred only

Statements

41 statements

41 statements · 3 reference databases · Subject: ACAN · Sources: Hetionet, Reactome, WikiPathways

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ACAN covaries with APOL6ProteinHetionet hetionet:covaries:176-80830Inferred only
ACAN covaries with C19orf73ProteinHetionet hetionet:covaries:176-55150Inferred only
ACAN covaries with FBN3ProteinHetionet hetionet:covaries:176-84467Inferred only
ACAN covaries with HSD17B6ProteinHetionet hetionet:covaries:176-8630Inferred only
ACAN covaries with KCNN1ProteinHetionet hetionet:covaries:176-3780Inferred only
ACAN interacts with ADAMTS1ProteinHetionet hetionet:interacts:176-9510Inferred only
ACAN interacts with ADAMTS4ProteinHetionet hetionet:interacts:176-9507Inferred only
ACAN interacts with ADAMTS5ProteinHetionet hetionet:interacts:11096-176Inferred only
ACAN interacts with CTSBProteinHetionet hetionet:interacts:1508-176Inferred only
ACAN interacts with FBLN1ProteinHetionet hetionet:interacts:176-2192Inferred only
ACAN interacts with FBLN2ProteinHetionet hetionet:interacts:176-2199Inferred only
ACAN interacts with HAPLN1ProteinHetionet hetionet:interacts:1404-176Inferred only

Show the remaining 29

ACAN interacts with LUMProteinHetionet hetionet:interacts:176-4060Inferred only
ACAN interacts with MMP1ProteinHetionet hetionet:interacts:176-4312Inferred only
ACAN interacts with MMP14ProteinHetionet hetionet:interacts:176-4323Inferred only
ACAN interacts with MMP2ProteinHetionet hetionet:interacts:176-4313Inferred only
ACAN interacts with MMP20ProteinHetionet hetionet:interacts:176-9313Inferred only
ACAN interacts with MMP3ProteinHetionet hetionet:interacts:176-4314Inferred only
ACAN interacts with MMP8ProteinHetionet hetionet:interacts:176-4317Inferred only
ACAN interacts with TNFAIP6ProteinHetionet hetionet:interacts:176-7130Inferred only
ACAN interacts with TNRProteinHetionet hetionet:interacts:176-7143Inferred only
ACAN participates in Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)PathwayReactome R-HSA-3656244Inferred only
ACAN participates in Defective CHST6 causes MCDC1PathwayReactome R-HSA-3656225Inferred only
ACAN participates in Defective ST3GAL3 causes MCT12 and EIEE15PathwayReactome R-HSA-3656243Inferred only
ACAN participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
ACAN participates in DiseasePathwayReactome R-HSA-1643685Inferred only
ACAN participates in Diseases associated with glycosaminoglycan metabolismPathwayReactome R-HSA-3560782Inferred only
ACAN participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
ACAN participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
ACAN participates in ECM proteoglycansPathwayReactome R-HSA-3000178Inferred only
ACAN participates in Endochondral ossificationPathwayWikiPathways WP474Inferred only
ACAN participates in Endochondral ossification with skeletal dysplasiasPathwayWikiPathways WP4808Inferred only
ACAN participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
ACAN participates in Glycosaminoglycan metabolismPathwayReactome R-HSA-1630316Inferred only
ACAN participates in Keratan sulfate biosynthesisPathwayReactome R-HSA-2022854Inferred only
ACAN participates in Keratan sulfate degradationPathwayReactome R-HSA-2022857Inferred only
ACAN participates in Keratan sulfate/keratin metabolismPathwayReactome R-HSA-1638074Inferred only
ACAN participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
ACAN participates in Metabolism of carbohydrates and carbohydrate derivativesPathwayReactome R-HSA-71387Inferred only
ACAN participates in Osteoarthritic chondrocyte hypertrophyPathwayWikiPathways WP5373Inferred only
ACAN participates in Spinal cord injuryPathwayWikiPathways WP2431Inferred only

Other names

8 names

Resolves to: ACAN

Also called: [Cleaved into: Aggrecan core protein 2]AGC1Cartilage-specific proteoglycan core proteinChondroitin sulfate proteoglycan 1Chondroitin sulfate proteoglycan core protein 1CSPCPCSPG1MSK16

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