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Proteins/UNIPROT:P01130
Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization..
(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins..
(Microbial infection) Acts as a receptor for Vesicular stomatitis virus..
(Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells..
(Microbial infection) Acts as a receptor for Crimean-Congo hemorrhagic fever virus (CCHFV)..
(Microbial infection) Acts as a receptor for many Alphavirus, including Getah virus (GETV), Ross river virus (RRV) and Semliki Forest virus..
Function from UniProtKB (P01130), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
96 statements
96 statements · 4 reference databases · Subject: LDLR · Sources: gene ontology, Hetionet, Reactome, WikiPathways
2 reactions
MAM03146eMAM03146l
Transported by LDLR
Reaction pageLeft to rightBalance undeterminableextracellular space, lysosome
Human-GEM MAR05241CC BY 4.0Reference data
MAM01569eMAM01569l
Transported by LDLR
Reaction pageLeft to rightBalance undeterminableextracellular space, lysosome
Human-GEM MAR05246CC BY 4.0Reference data
2 names
Resolves to: LDLR