CS/DS degradation

Lysosomal degradation of glycoproteins is part of the cellular homeostasis of glycosylation. The steps outlined below describe the degradation of chondroitin sulfate and dermatan sulfate. Complete degradation of glycoproteins is required to avoid build up of glycosaminoglycan fragments which can cause lysosomal storage diseases. Complete degradation steps are not shown as they are repetitions of the main ones described here. The proteolysis of the core protein of the glycoprotein is not shown here.

Summary from Reactome (R-HSA-2024101), read 2026-09-23.