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Proteins/UNIPROT:Q9Y666
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity)..
Function from UniProtKB (Q9Y666), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
54 statements
54 statements · 5 reference databases · Subject: SLC12A7 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
3 reactions
chlorine(.)+potassium atomchlorine(.)+potassium atom
Transported by SLC12A7 or SLC12A4 or SLC12A5 or SLC12A6
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05990CC BY 4.0Reference data
chlorine(.)+ammoniumchlorine(.)+ammonium
Transported by SLC12A7
3 names
Resolves to: SLC12A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06527CC BY 4.0Reference data
Transported by SLC12A5 or SLC12A6 or SLC12A4 or SLC12A7
Reaction pageDirection not assertedBalanced
Rhea RHEA:72427CC BY 4.0Reference data