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Proteins/UNIPROT:P22748
Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid..
Function from UniProtKB (P22748), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
14 statements
14 statements · 4 reference databases · Subject: CA4 · Sources: Hetionet, Reactome, UniProt, WikiPathways
2 reactions
carbon dioxide+waterproton+hydrogencarbonate
Catalysed by CA12 or CA2 or CA9 or CA14 or CA6 or CA4
Reaction pageReversibleBalancedEC 4.2.1.1extracellular space
Human-GEM MAR05407CC BY 4.0Reference data
3 names
Resolves to: CA4
Reaction pageReversibleBalanced
Rhea RHEA:10748CC BY 4.0Reference data