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Proteins/UNIPROT:Q6PIJ6
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity. Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival. May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity)..
Function from UniProtKB (Q6PIJ6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
40 statements
40 statements · 2 reference databases · Subject: FBXO38 · Sources: gene ontology, Hetionet
1 name
Resolves to: FBXO38