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Proteins/UNIPROT:P04920
Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane. Plays an important role in osteoclast differentiation and function. Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity)..
Function from UniProtKB (P04920), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
132 statements
132 statements · 8 reference databases · Subject: SLC4A2 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
chlorine(.)+hydrogencarbonatechlorine(.)+hydrogencarbonate
Transported by SLC4A1 or SLC26A4 or SLC26A3 or SLC4A9 or SLC4A3 or SLC4A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06525CC BY 4.0Reference data
9 names
Resolves to: SLC4A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:72363CC BY 4.0Reference data