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Proteins/UNIPROT:Q2Y0W8
Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons (By similarity). Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity)..
Function from UniProtKB (Q2Y0W8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
31 statements
31 statements · 6 reference databases · Subject: SLC4A8 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea
3 reactions
chlorine(.)+proton+hydrogencarbonate+sodium(1+)chlorine(.)+proton+hydrogencarbonate+sodium(1+)
Transported by SLC4A8 or SLC4A10
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR01525CC BY 4.0Reference data
7 names
Resolves to: SLC4A8
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06532CC BY 4.0Reference data
2hydrogencarbonate+chloride+sodium(1+)2hydrogencarbonate+chloride+sodium(1+)
Transported by SLC4A8 or SLC4A10 or SLC4A9
Reaction pageDirection not assertedBalanced
Rhea RHEA:72739CC BY 4.0Reference data