Proteins/UNIPROT:Q709C8

VPS13C

ProteinUNIPROT:Q709C8

Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization..

Function from UniProtKB (Q709C8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

autosomal recessive early-onset Parkinson disease 23 has a germline basis in VPS13CDiseaseGenCC HGNC:23594|MONDO:0014796Inferred only
young-onset Parkinson disease has a germline basis in VPS13CDiseaseGenCC HGNC:23594|MONDO:0017279Inferred only

Statements

10 statements

10 statements · 2 reference databases · Subject: VPS13C · Sources: gene ontology, Hetionet

Order

ADGRF5 covaries with VPS13CProteinHetionet hetionet:covaries:221395-54832Inferred only
B4GALNT2 covaries with VPS13CProteinHetionet hetionet:covaries:124872-54832Inferred only
BST2 covaries with VPS13CProteinHetionet hetionet:covaries:54832-684Inferred only
VPS13C covaries with PRTGProteinHetionet hetionet:covaries:283659-54832Inferred only
STARD9 covaries with VPS13CProteinHetionet hetionet:covaries:54832-57519Inferred only
ZNF394 covaries with VPS13CProteinHetionet hetionet:covaries:54832-84124Inferred only
UBC interacts with VPS13CProteinHetionet hetionet:interacts:54832-7316Inferred only
VPS13C regulates negative regulation of type 2 mitophagyBiological processgene ontology Q709C8|GO:1905090Inferred only
CA2 increases the expression of VPS13CProteinHetionet hetionet:regulates:760-54832Inferred only
WRN decreases the expression of VPS13CProteinHetionet hetionet:regulates:7486-54832Inferred only

Other names

3 names

Resolves to: VPS13C

Also called: Intermembrane lipid transfer protein VPS13CKIAA1421Vacuolar protein sorting-associated protein 13C

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