cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

371 compounds within 3 steps: 2 in 1, 77 in 2, 292 in 3

Two steps

(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
Catalysed by CEL, LIPA, ALOX15B, ALOX15 and 1 morelysosome
(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
Catalysed by CEL, LIPA, ALOX5lysosome
leukotriene A4Reach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O
Catalysed by CEL, LIPA, ALOX5lysosome
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine
Catalysed by CEL, LIPA, FAAH, PM20D1lysosome
18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. cytochrome P450 (arachidonate)
Catalysed by CEL, LIPA, CYP4F8lysosome, endoplasmic reticulumOne of 2 routes
(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
Catalysed by CEL, LIPA, ALOX12Blysosome
(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. Arachidonate:oxygen 8-oxidoreductase
Catalysed by CEL, LIPA, ALOX12lysosome, cytosolOne of 2 routes
2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerolReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. fatty acid amide hydrolase (arachidonate)
Catalysed by CEL, LIPA, FAAHlysosome, cytosol
(25R)-cholest-5-ene-3beta,26-diolReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. cholesterol,NADPH:oxygen oxidoreductase (5alpha,6alpha-epoxidizing)
Catalysed by CEL, LIPA, CYP27A1lysosome, mitochondrial matrix
20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. arachidonic acid:oxygen 1-oxidoreductase
Catalysed by CEL, LIPA, CYP1A1, CYP1A2 and 25 morelysosome, cytosolOne of 3 routes
11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CEL, LIPA, CYP2C9lysosome
19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CEL, LIPA, CYP1A1, CYP1A2 and 3 morelysosome
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by CEL, LIPA, PTGS2lysosomeOne of 2 routes
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by CEL, LIPA, PTGS2lysosomeOne of 2 routes
(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
Catalysed by CEL, LIPA, PTGS2lysosome
11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. Arachidonate: oxygen 11-oxidoreductase
Catalysed by CEL, LIPA, ALOX12lysosome, cytosolOne of 2 routes
prostaglandin G2Reach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. Arachidonate:oxygen oxidoreductase
Catalysed by CEL, LIPA, PTGS1, PTGS2lysosome, endoplasmic reticulumOne of 2 routes
cholesteryl octadecanoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. Acyl-CoA:cholesterol O-acyltransferase
Catalysed by CEL, LIPA, SOAT2, SOAT1lysosome, endoplasmic reticulum
(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CEL, LIPA, CYP2C9lysosome
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. unspecific monooxygenase (arachidonate)
Catalysed by CEL, LIPA, CYP1A1, CYP1A2 and 25 morelysosome, cytosolOne of 4 routes
8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. unspecific monooxygenase (arachidonate)
Catalysed by CEL, LIPA, CYP1A1, CYP1A2 and 24 morelysosome, cytosolOne of 3 routes
cholesteryl (8Z,11Z,14Z)-eicosatrienoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. Acyl-CoA:cholesterol O-acyltransferase
Catalysed by CEL, LIPA, SOAT2, SOAT1lysosome, endoplasmic reticulum
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserineReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoserine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by CEL, LIPA, ABHD16Alysosome
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by CEL, LIPA, ABHD16Alysosome
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by CEL, LIPA, ABHD16Alysosome
(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterolReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. Acyl-CoA:cholesterol O-acyltransferase
Catalysed by CEL, LIPA, SOAT2, SOAT1lysosome, endoplasmic reticulum
(18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CEL, LIPA, CYP4F8lysosome
15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
Catalysed by CEL, LIPA, ALOX15Blysosome
5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. sterol esterase (Cholesteryl Arachidonate)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
Catalysed by CEL, LIPA, ALOX15Blysosome

cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate

Two steps

Three steps